原著　Original Article 2008

1. M. Kitajima, A. Tanaka, N. Kogure, and H. Takayama :
Four new colchicinoids, gloriosamines A-D, from Gloriosa rothschildiana
Tetrahedron Lett.,49(2), 257-260 (2008).

2. Y. Matsuda, M. Kitajima, and H. Takayama :
First Total Synthesis of Trimeric Indole Alkaloid, Psychotrimine
Org. Lett.,10(1), 125-128 (2008).

3. Y. Nishikawa, M. Kitajima, and H. Takayama :
First Asymmetric Total Syntheses of Cernuane-Type Lycopodium Alkaloids, Cernuine, and Cermizine D
Org. Lett.,10(10), 1987-1990 (2008).

4. N. Kogure, H. Kobayashi, N. Ishii, M. Kitajima, S. Wongseripipatana, and H. Takayama :
New humantenine-type indole alkaloids with iridoid unit from Gelsemium species
Tetrahedron Lett.,49(22), 3638-3642 (2008).

5. N. Kogure, N. Ishii, H. Kobayashi, M. Kitajima, S. Wongseripipatana, and H. Takayama :
New Iridoids from Gelsemium Species.
Chem. Pharm. Bull.,56(6), 870-872 (2008).

6. Y. Yamada, M. Kitajima, N. Kogure, and H. Takayama :
Four novel gelsedine-type oxindole alkaloids from Gelsemium elegans
Tetrahedron,64(33), 7690-7694 (2008).

7. K. Matsumoto, H. Takayama, M. Narita, A. Nakamura, M. Suzuki, T. Suzuki, T. Murayama, S. Wongseripipatana, K. Misawa, M. Kitajima, K. Tashima, and S. Horie :
MGM-9 [(E)-Methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a Derivative of the Indole Alkaloid Mitragynine: A Novel Dual-acting m- and k-Opioid Agonist with Potent Antinociceptive and Weak Rewarding Effects in Mice.
Neuropharmacology,55(2), 154-165 (2008).

8. Y. Wu, M. Kitajima, N. Kogure, R. Zhang, and H. Takayama :
Two Novel Indole Alkaloids, Kopsiyunnanines A and B, from a Yunnan Kopsia
Tetrahedron Lett.,49(41), 5935-5938 (2008).

9. A. Nakayama, N. Kogure, M. Kitajima, and H. Takayama :
Straightforward Asymmetric Total Synthesis of (+)-Evodiamine, a Major Indole Alkaloid in Herbal Medicine "Wu Zhu Yu"
Heterocycles,76(1), 861-865 (2008).

10. Y. Toriizuka, E. Kinoshita, N. Kogure, M. Kitajima, A. Ishiyama, K. Otoguro, H. Yamada, S. Omura, and H. Takayama :
New Lycorine-type Slkaloid from Lycoris traubii and Evaluation of Antitrypanosomal and Antimalarial Activities of Lycorine Derivatives
Bioorg. Med. Chem.,16(24), 10182-10189 (2008).

11. M. A. Tan, H. Takayama, N. Aimi, M. Kitajima, S. G. Franzblau, and M. G. Nonato :
Antitubercular Triterpenes and Phytosterols from Pandanus tectorius Soland. var. laevis
J. Nat. Med.,62(2), 232-235 (2008).

12. H. Suzuki, R. Sasaki, Y. Ogata, Y. Nakamura, N. Sakurai, M. Kitajima, H. Takayama, S. Kanaya, K. Aoki, D. Shibata, and K. Saito :
Metabolic Profiling of Flavonoids in Lotus japonicus Using Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectropetry
Phytochemistry,69(1), 99-111 (2008).

13. S. Ferlinahayati, M. Yana, L. D. Juliawaty, S. A. Achmad, E. H. Hakim, H. Takayama, I. M. Said, and J. Latip :
Phenolic Constituents from the Wood of Morus australis with Cytotoxic Activity
Z. Naturforsch., C: J. Biosci.,63(1/2), 35-39 (2008).

14. A. H. Abou-Donia, S. M. Toaima, H. M. Hammoda, E. Shawky, E. Kinoshita, and H. Takayama :
Phytochemical and Biological Investigation of Hymenocallis littoralis SALISB
Chem. Biodiversity,5(2) , 332-340 (2008).

15. S. Jamil, H. M. Sirat, I. Jantan, N. Aimi, and M. Kitajima :
A New Prenylated Dihydrochalcone from the Leaves of Artocarpus lowii
J. Nat. Med.,62(3), 321-324 (2008).

16. R. Kaewamatawong, M. Kitajima, N. Kogure, and H. Takayama :
Flavonols from Bauhinia malabarica
J. Nat. Med.,62(3), 364-365 (2008).

17. K. Yonekura-Sakakibara, T. Tohge, F. Matsuda, R. Nakabayashi, H. Takayama, R. Niida, A. Watanabe-Takahashi, E. Inoue, and K. Saito :
Comprehensive Flavonol Profiling and Transcriptome Coexpression Analysis Leading to Decoding Gene-metabolite Correlations in Arabidopsis
Plant Cell,20(8), 2160-2176 (2008).

18. N. A. Saidin, T. Randall, H. Takayama, E. Holmes, and N. J. Gooderham :
Malaysian Kratom a Phyto-pharmaceuitical of Abuse: Studies on the Mechanism of its Cytotoxicity
Toxicology,253, 19-20 (2008).

原著 Original Article 2007

1. T. Shigeyama, K. Katakawa, N. Kogure, M. Kitajima, and H. Takayama :
Asymmetric Total Syntheses of Two Phlegmarine-Type Alkaloids, Lycoposerramines-V and -W, Newly Isolated from Lycopodium serratum.
Org. Lett.,9(20), 4069-4072 (2007).

2. K. Katakawa, A. Nozoe, N. Kogure, M. Kitajima, M. Hosokawa, and H. Takayama :
Fawcettimine-Related Alkaloids from Lycopodium serratum.
J. Nat. Prod.,70(6), 1024-1028 (2007).

3. H. Takayama, Y. Yaegashi, M. Kitajima, X. Han, K. Nishimura, S. Okuyama, and K. Igarashi :
Design, Synthesis and Biological Evaluation of Tricyclic Heterocycle-Tetraamine Conjugates as Potent NMDA Channel Blockers.
Bioorg. Med. Chem. Lett.,17(17), 4729-4732 (2007).

4. M. Kitajima :
Chemical Studies on Monoterpenoid Indole Alkaloids from Medicinal Plant Resource Gelsemium and Ophiorrhiza.
J. Nat. Med.,61(1), 14-23 (2007).

5. M. Kitajima, T. Nakayama, N. Kogure, S. Wongseripipatana, and H. Takayama :
New Heteroyohimbine-type Oxindole Alkaloid from Leaves of Thai Mitragyna hirsuta.
J. Nat. Med.,61(2), 192-195 (2007).

6. N.Kogure, A. Someya, A. Urano, M. Kitajima, and H. Takayama :
Total Synthesis and Full NMR Assignment of Ourouparine, a Yohimbane-type Indole Alkaloid Isolated from Gelsemium sempervirens.
J. Nat. Med.,61(2), 208-212 (2007).

7. N. Okada, K. Misawa, M. Kitajima, and H. Takayama :
Preparation of Ethylene Glycol Adducts at 2,3-Positions of Indoles with Hypervalent Iodine.
Heterocycles,74, 461-472 (2007).

8. L. Jin, H. Sugiyama, M. Takigawa, D. Katagiri, H. Tomitori, K. Nishimura, N. Kaur, O. Phanstiel IV, M. Kitajima, H. Takayama, T. Okawara, K. Williams, K. Kashiwagi, and K. Igarashi :
Comparative Studies of Anthraquinone- and Anthracene- Tetraamines as Blockers of N-Methyl-D-aspartate Receptor.
J. Pharmacol. Exp. Ther.,320(1), 47-55 (2007).

9. D. Susanti, H. M. Sirat, F. Ahmad, R. M. Ali, N. Aimi, and M. Kitajima :
Antioxidant and Cytotoxic Flavonoids from the Flowers of Melastoma malabathricum L.
Food Chemistry,103(3), 710-716 (2007) and107 (3), 1275 (2008).

原著　Original Article 2006

1. N. Kogure, N. Ishii, M. Kitajima, S. Wongseripipatana, and H. Takayama :
“Four Novel Gelsenicine-Related Oxindole Alkaloids from the Leaves of Gelsemium
elegans Benth.”
Org. Lett.,8(14), 3085-3088 (2006).

2. K. Suzuki and H. Takayama :
“First Asymmetric Total Syntheses of (-)-Subincanadines A and B, Skeletally Rearranged Pentacyclic Monoterpenoid Indole Alkaloids in Aspidosperma subincanum.”
Org. Lett.,8(20) 4605-4608 (2006).

3. H. Takayama, K. Misawa, N. Okada, H. Ishikawa, M. Kitajima, Y. Hatori, T. Murayama, S. Wongseripipatana, K. Tashima, K. Matsumoto, and S. Horie :
“New Procedure to Mask the 2,3-p Bond of the Indole Nucleus and Its Application to the Preparation of Potent Opioid Receptor Agonists with a Corynanthe Skeleton.”
Org. Lett.,8(25) 5705-5708 (2006).

4. M. Kitajima, I. Mori, K. Arai, N. Kogure, and H. Takayama :
“Two new tryptamine-derived alkaloids from Chimonanthus praecox f. concolor.”
Tetrahedron Lett.,47(19), 3199-3202 (2006).

5. M. Kitajima, T. Nakamura, N. Kogure, M. Ogawa, Y. Mitsuno, K. Ono, S. Yano, N. Aimi, and H. Takayama :
“Isolation of Gelsedine-type Indole Alkaloids from Gelsemium elegans and Evaluation of the Cytotoxic Activity of Gelsemium Alkaloids for A431 Epidermoid Carcinoma Cells.”
J. Nat. Prod.,69(4), 715-718 (2006).

6. M. Kitajima, K. Misawa, N. Kogure, I. M. Said, S. Horie, Y. Hatori, T. Murayama, and H. Takayama :
“A New Indole Alkaloid, 7-Hydroxyspeciociliatine, from the Fruits of Malaysian Mitragyna speciosa and its Opioid Agonistic Activity.”
J. Nat. Med.,60(1), 28-35 (2006).

7. E. H. Hakim, S. A. Achmad, L. D. Juliawaty, L. Makmur, Y. M. Syah, N. Aimi, M. Kitajima, H. Takayama, and E. L. Ghisalberti :
“Prenylated Flavonoids and Related Compounds of the Indonesian Artocarpus (Moraceae). “
J. Nat. Med.,60(3), 161-184 (2006).

8. K. Katakawa, M. Kitajima, K. Yamaguchi, and H. Takayama :
“Three New Phlegmarine-Type Lycopodium Alkaloids, Lycoposerramines-X, -Y and –Z, Having a Nitrone Residue, from Lycopodium serratum.”
Heterocycles,69, 223-229 (2006).

9. K. Matsumoto, H. Takayama, H. Ishikawa, N. Aimi, D. Ponglux, K. Watanabe, S. Horie :
“Partial Agonistic Effect of 9-Hydroxycorynantheidine on m-Opioid Receptor in the Guinea-pig Ileum.”
Life Sci.,78(19), 2265-2271 (2006).

10. K. Matsumoto, Y. Hatori, T. Murayama, K. Tashima, S. Wongseripipatana, K. Misawa, M. Kitajima, H. Takayama, and S. Horie :
“Involvement of m-Opioid Receptors in Antinociception and Inhibition of Gastrointestinal Transit Induced by 7-Hydroxymitragynine, Isolated from Thai Herbal Medicine Mitragyna speciosa.”
Eur. J. Pharmacolo.,549(1-3), 63-70 (2006).

11. H. Usman, E. H. Hakim, T. Harlim, M. N. Jalaluddin, Y. M. Syah, S. A. Achmad, and H. Takayama :
“Cytotoxic Chalcones and Flavanones from the Tree Bark of Cryptocarya costata. “
Z.Naturforsch., C,61(3/4), 184-188 (2006).

12. Y. M. Syah, S. A. Achmad, N. Aimi, E. H. Hakim, L. D. Juriawaty, and H. Takayama :
“Two prenylated flavones from the tree bark of Artocarpus lanceifolius.”
Z.Naturforsch., B,61(9), 1134-1137 (2006).