原著 Original Article 2021

1. Allen Yi-Lun Tsai, Yuka Iwamoto, Yoichi Tsumuraya, Morihiro Oota, Teruko Konishi, Shinsaku Ito, Toshihisa Kotake, Hayato Ishikawa and Shinichiro Sawa*
Root-Knot nematode chemotaxis is positively regulated by L-garactose sidechains of mucilage carcohydrate rhamnogalacturonan-Ⅰ
Science AdvancesDOI: https://doi.org/10.1126/sciadv.abh4182

2. Takashi Ishida*, Haruna Yoshimura, Masatsugu Takekawa, Takumi Higaki, Takashi Ideue, Masaki Hatano, Masayuki Igarashi, Tokio Tani, Shinichiro Sawa, Hayato Ishikawa*
Discovery, Characterization and Functional Improvement of Kumamonamide as a Novel Plant Growth Inhibitor that Disturb Plant Microtubules
Sci. Rep. DOI:10.1038/s41598-021-85501-1

3. T. Onozawa, N. Kogure, H. Takayama, and M. Kitajima:
Elucidation of Absolute Configuration of Ophiorrhiside A by Comparison of ECD Spectra with That of Model Chiral Compound Having a 1,2,3,4-Tetrahydro-β-carbolin-3-on Skeleton.
Heterocycles,102(1), 35-43 (2021).

 

4. E. Hermawati*, S. D. Ellita, L. D. Juliawaty, E. H. Hakim, Y. M. Syah, H. Ishikawa
Epoxyquinophomopsins A and B from Endophytic Fungus Phomopsis sp. and Their Activity against Tyrosine Kinase
J. Nat. Med.75, 217–222 (2021).

総説・単行書等 Review, Monograph, etc 2021

1. 塩見慎也*、石川勇人*：光学活性キニーネの全合成、有機合成化学協会誌（Journal of Synthetic
Organic Chemistry, Japan）、79, 145–154 (2021).

原著 Original Article 2020

1. H. Sugama, T. Matsudaira, H. Yanagisawa, R. Ohashi, M. Nawano, K. Yasuda, and H. Takayama
Design, Synthesis, and Pharmacological Evaluation of 2-(4-Sulfonylphenyl)-2-[(E)-pyrrolidin-1- ylimino]-N-thiazoleacetamides as Glucokinase Activators.
Bioorg. Med. Chem. Lett.,30(15), 127249 (2020).

2. Jukiya Sakamoto, Yuhei Umeda, Kenta Rakumitsu, Michinori Sumimoto,Hayato Ishikawa*
Total Syntheses of (–)-Strictosidine and Related Indole Alkaloid Glycosides
Angew. Chem., Int. Ed.,59, 13414–13422 (2020).

 

3. L. D. Juliawaty*, P. N. Ra’idah, S. Abdurrahman, E. Hermawati, A. Alni, M. I. Tan, H. Ishikawa, Y. M. Syah
5,6-Dihydro-α-pyrones from the Leaves of Cryptocarya pulchinervia (Lauraceae)
J. Nat. Med.74, 584–590 (2020).

4. Makoto Matsumoto, Kohei Wada, Kazuki Urakawa, Hayato Ishikawa*
Diaryliodonium Salt-Mediated Intramolecular C–N Bond Formation Using Boron-Masking N-Hydroxyamides.
Org. Lett.,22, 781–785 (2020).
Selected “Cover Picture”

 

5. M. Oota, A. Y.-L. Tsai, D. Aoki, Y. Matsushita, S. Toyoda, K. Fukushima, K. Saeki, K. Toda, L. Perfus-Barbeoch, B. Favery, H. Ishikawa*, S. Sawa*
Identification of Naturally-Occurring Polyamines as Nematode Meloidogyne incognita Attractants
Mol. Plant13. 658–665 (2020).

 

総説・単行書等 Review, Monograph, etc 2020

1. H. Takayama:
Total Syntheses of Lycopodium and Monoterpenoid Indole Alkaloids Based on Biosynthesis-Inspired Strategies.
Chem.Pharm.Bull.,68(2), 103-116 (2020).

 

 

原著 Original Article 2019

1. H. Kawabata, T. Hirama, T. Yanagisawa, K. Sato, N. Kogure, M. Kitajima, and H. Takayama:
Asymmetric Total Synthesis of Biphenylquinolizidine Alkaloids 4”-O-Demethyllythridine and 14-epi-4”-O-Demethyllythridine.
Org. Lett.,21(19), 7982-7986 (2019).

2. A. Saito, N. Kogure, M. Kitajima, and H. Takayama:
Total Synthesis of (–)-14-Hydroxygelsenicine and Six Biogenetically Related Gelsemium Alkaloids.
Org. Lett.,21(17), 7134-7137 (2019).

3. K. Sato, N. Kogure, M. Kitajima, and H. Takayama:
Total Syntheses of Pleiocarpamine, Normavacurine, and C-Mavacurine.
Org. Lett.,21(9), 3342-3345 (2019).

4. H. Kaneko, S. Takahashi, N. Kogure, M. Kitajima, and H. Takayama:
Asymmetric Total Synthesis of Fawcettimine-Type Lycopodium Alkaloid, Lycopoclavamine-A.
J. Org. Chem.,84(9), 5645-5654 (2019).

5. K. Wada, N. Kogure, M. Kitajima, and H. Takayama:
Concise Asymmetric Total Synthesis of Lycopodine and Flabelliformine via Cascade Cyclization Reaction.
Tetrahedron Lett.,60(2), 187-190 (2019).

6. M. Kitajima, Y. Yamaguchi, T. Yanagisawa, N. Kogure, J. Ogata, R. Kikura-Hanajiri, and H. Takayama:
Biphenyl quinolizidine lactone alkaloids from "sinicuichi" (Heimia salicifolia).
Tetrahedron,75(27), 3733-3739 (2019).

7. M. Kitajima, K. Okabe, M. Yoshida, R. Nakabayashi, K, Saito, N. Kogure, and H. Takayama:
New Otonecine-type Pyrrolizidine Alkaloid from Petasites japonicus.
J. Nat. Med.,73(3), 602-607 (2019).

8. M. Kitajima, S. Nakano, N. Kogure, S. Subhadhirasakul, and H. Takayama:
New Indole Alkaloids from Ervatamia cumingiana.
Heterocycles,99(1), 213-221 (2019).

 

総説・単行書等 Review, Monograph, etc 2019

1. M. A. Tan and H. Takayama:Recent Progress in the Chemistry of Pandanus Alkaloids. “The Alkaloids: Chemistry and Biology”, ed. by Hans-Joachim Knölker, Academic Press, Vol. 82, p. 1-28 (Chapter 1) (2019).

原著 Original Article 2018

1. M. Kitajima, T. Yanagisawa, M. Tsukahara, Y. Yamaguchi, N. Kogure, R. Kikura-Hanajiri, Y. Goda, O. Iida, Y. Sugimura, N. Kawahara, and H. Takayama:
Biphenyl Ether and Biphenyl Quinolizidine Lactone Alkaloids from Heimia salicifolia.
Tetrahedron,74(4), 441-452 (2018).

2. K. Sato, N. Takanashi, N. Kogure, M. Kitajima, and H. Takayama:
Formal Total Synthesis of (±)-Strictamine.
Heterocycles,97(1), 365-382 (2018).

3. T. Onozawa, M. Kitajima, N. Kogure, and H. Takayama:
Asymmetric Total Synthesis and Evaluation of Antitumor Activity of Ophiorrhisine A and Its Derivatives.
J. Org. Chem.,83(24), 15312-15322 (2018).

4. T. Uemura, K. Watanabe, K. Ko, K. Higashi, N. Kogure, M. Kitajima, H. Takayama, K. Takao, Y. Sugita, A. Sakamoto, Y. Terui, T. Toida, K. Kashiwagi, and K. Igarashi:
Protective Effects of Brain Infarction by N-Acetylcysteine Derivatives.
Stroke,49(7), 1727-1733 (2018).

総説・単行書等 Review, Monograph, etc 2018

1. 高山廣光（分担執筆）：天然毒性物質、トキシコロジー　第３版　（日本毒性学会教育委員会編、朝倉書店）111-118 (2018).

2. 高山廣光（分担執筆）：インドールアルカロイド／ヒトを虜にする不思議な力、天然物の化学II　（上村大輔編、東京化学同人）148-154 (2018).

3. 小暮紀行：アンドランギニンの不斉全合成と天然物の絶対立体配置について（特集号 天然物化学はおもしろい！）, 有機合成化学協会誌, 76 (5), 446-449 (2018).

原著 Original Article 2017

1. T. Hirama, T. Umemura, N. Kogure, M. Kitajima, and H. Takayama:
Synthetic Study of Biphenylquinolizidine Alkaloids I. Asymmetric Total Synthesis of Lasubine I Featuring Organocatalyzed Asymmetric Intramolecular aza-Michael Addition.
Tetrahedron Lett.,58(3), 223-226 (2017).

2. M. Kitajima, A. Morita, S. Endo, N. Kogure, K. Higashi, K. Moribe, and H. Takayama:
Design and Synthesis of 4-Chlorocolchicine-Derived Prodrug Capable of Forming Nanoparticles by Self-assembly.
Heterocycles,95(1), 181-186 (2017).

3. S. Tooriyama, Y. Mimori, Y. Wu, N. Kogure, M. Kitajima, and H. Takayama:
Asymmetric Total Synthesis of Pentacyclic Indole Alkaloid Andranginine and Absolute Configuration of Natural Product Isolated from Kopsia arborea.
Org. Lett.,19(10), 2722-2725 (2017).

4. T. Onozawa, M. Kitajima, N. Kogure, N. Peerakam, D. Santiarworn, and H. Takayama:
A Cyclopeptide and a Tetrahydroisoquinoline Alkaloid from Ophiorrhiza nutans.
J. Nat. Prod.,80(7), 2156-2160 (2017).

5. N. Cho, K. Kobayashi, M. Yoshida, N. Kogure, H. Takayama, and K. Chiba:
Identification of Novel Glutathione Adducts of Benzbromarone in Human Liver Microsomes.
Drug. Metab. Pharmacokinet.,32(1), 46-52 (2017).

総説・単行書等 Review, Monograph, etc 2017

1. 北島満里子: 薬用資源植物からの生物活性アルカロイドの探索. 月刊ファインケミカル, 46 (6), 20-27 (2017).

2. 高山廣光: 序章 Overview アルカロイド研究の概観, アルカロイドの科学, 高山廣光編, 京都, 化学同人, 1-10 (2017).

3. 北島満里子: 第2章 モノテルペノイドインドールアルカロイド, アルカロイドの科学, 高山廣光編, 京都, 化学同人, 35-64 (2017).

4. 高山廣光: 第9章 生合成にヒントを得たアルカロイドの化学合成, アルカロイドの科学, 高山廣光編, 京都, 化学同人, 169-190 (2017).

原著 Original Article 2016

1. N. Takanashi, K. Suzuki, M. Kitajima, and H. Takayama:
Total Synthesis of Conolidine and Apparicine.
Tetrahedron Lett.,57(3), 375-378 (2016).

2. M. Kitajima, K. Watanabe, H. Maeda, N. Kogure, and H. Takayama:
Asymmetric Total Synthesis of Sarpagine-Related Indole Alkaloids Hydroxygardnerine, Hydroxygardnutine, Gardnerine, (E)-16-epi-Normacusine B, and Koumine.
Org. Lett.,18(8), 1912-1915 (2016).

3. N. Kogure, M. Maruyama, S. Wongseripipatana, M. Kitajima, and H. Takayama:
New Lycopodine-type Alkaloids from Lycopodium carinatum.
Chem. Pharm. Bull.,64(7), 793-799 (2016).

4. R. Tokuda, Y. Okamoto, T. Koyama, N. Kogure, M. Kitajima, and H. Takayama:
Asymmetric Total Synthesis of Kopsiyunnanine K, a Monoterpenoid Indole Alkaloid with a Rearranged Skeleton.
Org. Lett.,18(14), 3490-3493 (2016).

5. M. Kitajima, M. Nakazawa, Y. Wu, N. Kogure, R. Zhang, and H. Takayama:
Kopsiyunnanines L and M, Strychnos-related Monoterpenoid Indole Alkaloids from Yunnan Kopsia arborea.
Tetrahedron,72(42), 6692-6696 (2016).

6. T. Tohge, R. Wendenburg, H. Ishihara, R. Nakabayashi, M. Watanabe, R. Sulpice, R. Hoefgen, H. Takayama, K. Saito, M. Stitt, and A. R. Fernie:
Characterization of a Recently Evolved Flavonol-Phenylacyltransferase Gene Provides Signatures of Natural Light Selection in Brassicaceae.
Nature Commun., 7:12399/DOI:10.1038/ncomms12399 (2016).

 

総説・単行書等 Review, Monograph, etc 2016

1. M. Kitajima and H. Takayama:
Monoterpenoid Bisindole Alkaloids.
“The Alkaloids: Chemistry and Biology”, ed. by Hans-Joachim Knölker, Academic Press, Vol. 76, p. 259-309 (Chapter 4) (2016).

2. 高山廣光（分担執筆）: アルカロイド及びその他の含窒素化合物, パートナー天然物化学　改訂第３版　第５章（南江堂）178-208 (2016).

3. 高山廣光（分担執筆）:自然が生み出す薬物, スタンダード薬学シリーズII ３, III.（日本薬学会編, 東京化学同人）198-213 (2016).