原著　Original article 2000-2001

1. M. Kitajima, K. Hashimoto, M. Yokoya, H. Takayama, and N. Aimi :
Two New 19-Hydroxyursolic Acid-type Triterpenes from Peruvian 'Uña de Gato" (Uncariatomentosa).
Tetrahedron,56, 547-552 (2000).

2. L. Makmur, Syamsurizal, Tukiran, S. A. Achmad, N. Aimi, E. H. Hakim, M. Kitajima, and H. Takayama :
Artoindonesianin C, a New Xanthone Derivative from Artocarpus teysmanii.
J. Nat. Prod.,63, 243-244 (2000).

3. K. Masuda, T. Akiyama, M. Taki, S. Takaishi, Y. Iijima, M. Yamazaki, N. Aimi, J. Jato, and P. G. Waterman :
Isolation of 10-Hydroxycoronaridine from Tabernaemontana penduliflora and its Estrogen-like Activity.
Planta Medica,66, 169-171 (2000).

4. H. Takayama, M. Kurihara, M. Kitajima, I. M. Said, and N. Aimi :
Structure Elucidation and Chiral-Total Synthesis of a New Indole Alklaoid, (±)-9-Methoxymitralactonine, Isolated from Mitragyna speciosa in Malaysia.
Tetrahedron,56, 3145-3151 (2000).

5. Jasril, N. H. Lajis, M. A. Abdullah, N. H. Ismail, A. M. Ali, M. Marziah, A. B. Ariff, M. Kitajima, H. Takayama, and N. Aimi :
Anthraquinones from Cell Suspension Culture of Morinda elliptica.
Nat. Prod. Sci., 6, 40-43 (2000).

6. S. Subhadhirasakul, H. Takayama, M. Kitajima, and N. Aimi :
Triterpenoids from Thai Medicinal Plant, Willughbeia firma.
Nat. Med.,54, 155-157 (2000).

7. H. Takayama, F. Watanabe, A. Kuroda, M. Kitajima, and N. Aimi :
Formation of a Novel 1-Aza-tricyclo[5.3.0.04,8]decane System via Tandem Radical Cyclization of a Tryptophan Derivative.
Tetrahedron,56, 6457-6461 (2000).

8. H. Takayama, T. Ichikawa, T. Kuwajima, M. Kitajima, H. Seki, N. Aimi, and M. G. Nonato :
Structure Characterization, Biomimetic Total Synthesis, and Optical Purity of Two New Pyrrolidine Alkaloids, Pandamarilactonine-A and -B, Isolated from Pandanus amaryllifolius Roxb.
J. Am. Chem. Soc.,122, 8635-8639 (2000).

9. M. Kitajima, K. Hashimoto, M. Yokoya, H. Takayama, and N. Aimi :
A New Gluco Indole Alkaloid, 3, 4-Dehydro-5-carboxystrictosidine, from Peruvian Uña de Gato (Uncaria tomentosa).
Chem. Pharm. Bull.,48, 1410-1412 (2000).

10. L. D. Juliawaty, M. Kitajima, H. Takayama, S. A. Achmad, and N. Aimi :
A 6-Substituted-5,6-dihydro-2-pyrone from Cryptocarya strictifolia.
Phytochem.,54. 989-993 (2000).

11. L. D. Juliawaty, M. Kitajima, H. Takayama, S. A. Achmad, and N. Aimi :
A New Type of Stilbene-Related Secondary Metabolite, Idenburgene, from Cryptocaryaidenburgensis.
Chem. Pharm. Bull.,48, 1726-1728 (2000).

12. A.-F. Mohamed A.-F. K. Matsumoto, K. Tabata, H. Takayama, M. Kitajima, N. Aimi, and H. Watanabe :
Effects of Uncaria tomentosa Total Alkaloid and its Components on Experimental Amnesia in Mice: Elucidation Using the Passive Avoidance Test.
J.Pharm. Pharmacol.,52, 1553-1561 (2000).

13. H. Takayama, H. Ishikawa, M. Kurihara, M. Kitajima, S. Sakai, N. Aimi, H. Seki, K. Yamaguchi, I. M. Said, and P. J. Houghton :
Structure Revision of Mitragynaline, an Indole Alkaloid in Mitragyna speciosa.
Tetrahedron Lett.,42, 1741-1743 (2001).

14. H. Takayama, T. Ichikawa, M. Kitajima, N. Aimi, D. Lopez, and M.G. Nonato :
A New Alkaloid, Pandanamine; Finding of an anticipated Biogenetic Intermediate in Pandanusamaryllifolius.
Tetrahedron Lett.,42, 2995-2996 (2001).

15. K. Saito, H. Sudo, M. Yamazaki, M. Koseki-Nakamura, M. Kitajima, H. Takayama, and N. Aimi : Feasible Production of Camptothecin by Hairy Root Culture of Ophiorrhiza pumila.
Plant Cell Rep.,20, 267-271 (2001).

16. K. Husain, I. Jantan, N. Kamaruddin, I. M. Said, N. Aimi, and H. Takayama :
Methyl Chanofruticosinates from leaves of Kopsia flavida Blume.
Phytochem.,57, 603-606 (2001).

17. D. Permana, N. J. Lajis, M. M. Mackeen, A. M. Ali, N. Aimi, M. Kitajima, and H. Takayama : Isolation and Bioactivities of Constituents of the Roots of Garcinia atroviridis.
J. Nat. Prod.,64, 976-979 (2001).

18. J. Nagakubo, T. Tomimatsu, M. Kitajima, H. Takayama, N. Aimi, and T. Horie :
Characteristic of Transport of Fluoresceinated Methotrexate in Rat Small Intestine.
Life Sciences,69, 739-747 (2001).

19. H. Takayama, T. Ichikawa, M. Kitajima, M. G. Nonato, and N. Aimi :
Isolation and Characterization of Two New Alkaloids, Norpandamarilactonine-A and -B, from Pandanus amaryllifolius by Spectroscopic and Synthetic Methods.
J. Nat. Prod.,64, 1224-1225 (2001).

20. H. Takayama, K. Katakawa, M. Kitajima, H. Seki, K. Yamaguchi, and N. Aimi :
A New Type of Lycopodium Alkaloid, Lycoposerramine-A, from Lycopodium serratum Thunb.
Org. Lett.,3, 4165-4167 (2001).

21. M. Kitajima, M. Yokoya, H. Takayama, and N. Aimi :
Co-occurrence of Harman and b-Carboline-type Monoterpenoid Glucoindole Alkaloids in Uña de Gato (Uncaria tomentosa).
Nat. Med.,55, 308-310 (2001).

22. T. Suhartati, S. A. Achmad, N. Aimi, E. H. Hakim, M. Kitajima, H. Takayama, and K. Takeya :
Artoindonesianin L, a New Prenylated Flavone with Cytotoxic Activity from Artocarpus rotunda.
Fitoterapia,72, 912-918 (2001).

総説・単行書等 Review, Monograph, etc 2000-2001

1. 相見則郎 : 正倉院の「冶葛」（やかつ）. 化学と教育, 48, 103-105 (2000).

2. 相見則郎（分担執筆） : 図説　正倉院薬物. 中央公論新社 (2000).

3. 相見則郎（分担執筆） : 生薬成分の化学：アルカロイド. 漢方薬・生薬薬剤師講座テキスト-3, 91-109（財）日本薬剤師研究センター (2000).

4. 相見則郎 : 正倉院薬物の学術調査. 千葉大学大学院薬学研究院の成果—薬学の世界をのぞく, 千葉日報 (2001).

5. 高山廣光（分担編集） : 薬学生・新人薬剤師のための知っておきたい医薬品選400−2001年版−. じほう (2001).

原著　Original article 2002-2003

1. Y. Ogra, K. Ishiwata, H. Takayama, N. Aimi, and K. T. Suzuki :
Identification of a Novel Selenium Metabolite, Se-methyl-N-acetylselenohexosamine, in Rat Urine by High-Performance Liquid Chromatography–Inductively Coupled Plasma Mass Spectroscopy and –Electrospray Ionization Tandem Mass Spectrometry.
J. Chromatography B,767(2), 301-312 (2002).

2. H. Takayama, H. Ishikawa, M. Kurihara, M. Kitajima, N. Aimi, D. Ponglux, F. Koyama, K. Matsumoto, T. Moriyama, L. T. Yamatomo, K. Watanabe, T. Murayama, and S. Horie :
Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids: Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands.
J. Med. Chem.,45(9), 1949-1956 (2002).

3. T.-Y. Kang, K. Matsumoto, M. Tohda, Y. Murakami, H. Takayama, M. Kitajima, N. Aimi, and H. Watanabe :
Pteropodine and Isopteropodine Positively Modulate the Function of Rat Muscarinic M1 and 5-HT2 Receptors Expressed in Xenopus oocyte.
Eur. J. Pharmacol.,444(1-2), 39-45 (2002).

4. S. Tsuchiya, S. Miyashita, M. Yamamoto, S. Horie, S. Sakai, N. Aimi, H. Takayama, and K. Watanabe :
Effects of Mitragynine, Derived from Thai Folk Medicine, on Gastric Acid Secretion through Opioid Receptor in Anesthetized Rats.
Eur. J. Pharmacol.,443(1-3), 185-188 (2002).

5. S. Zhang, Y. Murakami, M. Tohda, K. Matsumoto, I. Sakakibara, H. Takayama, N. Aimi, and H. Watanabe :
Protective Effect of Choto-san, Chotoko and its Alkaloids on Experimental Vascular Dementia in Mice: Elucidation Using Morris Water Maze Test.
Wakan Iyakugaku Zasshi,19(1), 28-36 (2002).

6. R. Kaewamatawong, K. Likhitwitayawuid, N. Ruangrungsi, H. Takayama, M. Kitajima, and N. Aimi : Novel Biflavonoids from the Stem Bark of Ochna integerrima.
J. Nat. Prod.,65(7), 1027-1029 (2002).

7. H. Takayama, H. Ishikawa, M. Kitajima, and N. Aimi :
Formation of an Unusual Dimeric Compound by Lead Tetraacetate Oxidation of a Corynanthe-Type Indole Alkaloid, Mitragynine.
Chem. Pharm. Bull.,50, (7) 960-963 (2002).

8. H. Sudo, T. Yamakawa, M. Yamazaki, N. Aimi, and K. Saito :
Bioreactor Production of Camptothecin by Hairy Root Cultures of Ophiorrhiza pumila.
Biotech. Lett.,24, (5) 359-363 (2002).

9. H. Ishikawa, H. Takayama, and N. Aimi :
Dimerization of Indole Derivatives with Hypervalent Iodines(III): a New Entry for the Concise Total Synthesis of rac- and meso-Chimonanthines.
Tetrahedron Lett.,43(32), 5637-5639 (2002).

10. H. Takayama, M. Arai, M. Kitajima, and N. Aimi :
First Total Synthesis of a Novel Monoterpenoid Isoquinoline Alkaloid, (±)-Alangine.
Chem. Pharm. Bull.,50(8), 1141-1143 (2002).

11. H. Takayama, T. Ichikawa, M. Kitajima, M. G. Nonato, and N. Aimi :
Isolation and Structure Elucidation of Two New Alkaloids, Pandamarilactonine-C and -D, from Pandanus amaryllifolius and Revision of Relative Stereochemistry of Pandamarilactonine-A and -B by Total Synthesis.
Chem. Pharm. Bull.,50(9), 1303-1304 (2002).

12. M. Kitajima, M. Yokoya, H. Takayama, and N. Aimi :
Synthesis and Absolute Configuration of a New 3,4-Dihydro-b-carboline-Type Alkaloid, 3,4-Dehydro-5(S)-5-carboxystrictosidine, Isolated from Peruvian Uña de Gato (Uncaria tomentosa).
Chem. Pharm. Bull.,50(10), 1376-1378 (2002).

13. W.-Y. Ahmad, I. M. Said, S.-Y. Soon, H. Takayama, M. Kitajima, and N. Aimi :
A Pterocarpan from Erythrina variegata.
OnlineJournal of Biological Sciences,2(8), 542-544 (2002).

14. H. Takayama, K. Katakawa, M. Kitajima, and N. Aimi :
Seven New Lycoposium Alkaloids, Lycoposerramines, from Lycposium serratum Thunb.
Tetrahedron Lett.,43(46), 8307-8311 (2002).

15. N. S. Aminah, S. A. Achmad, N. Aimi, E. L. Ghisalberti, E. H. Hakim, M. Kitajima, Y. M. Syah, and H. Takayama :
Diptoindonesin A, a New C-Glucoside of e-Viniferin from Shorea seminis.
Fitoterapia,73(6), 501-507 (2002).

16. L. D. Juliawaty, Y. Watanabe, M. Kitajima, S. A. Aachmad, H. Takayama, and N. Aimi :
First Total Synthesis and Determination of the Absolute Configuration of Strictifolione, a New 6-(w-Phenylalkenyl)-5,6-dihydro-a-pyrone, Isolated from Cryptocarya strictifolia.
Tetrahedron Lett.,43(48), 8657-8660 (2002).

17. N. Aimi, M. Kitajima, M. Yokoya, H. Takayama, S. Sakamoto, and K. Yamaguchi :
Collision-Induced Dissociation Actualized the H+-Promoted Reaction as Observed in Vitro; Harman Formation from b-Carboline-Type Monoterpenoid Glucoindole Alkaloids.
Chem. Pharm. Bull.,50(11), 1528-1529 (2002).

18. M. Kitajima, S. Yoshida, K. Yamagata, M. Nakamura, H. Takayama, K. Saito, and N. Aimi :
Camptothecin-related Alkaloids from Hairy Roots of Ophiorrhiza pumila.
Tetrahedron,58(45), 9169-9178 (2002).

19. T.-H. Kang, Y. Murakami, K. Matsumoto, H. Takayama, M. Kitajima, N. Aimi, and H. Watanabe :
Rhynchophylline and Isorhynchophylline Inhibit NMDA Receptors Expressed in Xenopus oocyte.
Eur. J. Pharmacol.,455(1), 27-34 (2002).

20. M. Kitajima, M. Niwa, C. Yanagisawa, H. Takayama, H. Sudo, K. Saito, and N. Aimi :
Camptothecin-related Akaloids from Culture Medium of Hairy Roots of Ophiorrhiza pumila.
Natural Medicines,56(6), 275 (2002).

21. E. H. Hakim, Asnizar, Yurnawilis, N. Aimi, M. Kitajima, and H. Takayama :
Artoindonesianin P, a New Prenylated Flavone with Cytotoxic Activity from Artocarpus lancelifolius.
Fitoterapia,73(7-8) 668-673 (2002).

22. Y. Kobayashi, Y. Ogra, K. Ishiwata, H. Takayama, N. Aimi, and K. T. Suzuki :
Selenosugars are Key and Urinary Metabolites for Selenium Excretion within the Required to Low-toxic Range.
PNAS,99(25), 15932-15936 (2002).

23. H. Takayama, S. Tsutsumi, M. Kitajima, D. Santiarworn, B. Liawruangrath, and N. Aimi :
Gluco-indole Alkaloids from Nauclea cadamba in Thailand and Transformation of 3a-Dihydrocadambine into the Indolopyridine Alkaloid, 16-Carbomethoxynaufoline.
Chem. Pharm. Bull.,51(2), 232-233 (2003).

24. M. Kitajima, K. Hashimoto, M. Yokoya, H. Takayama, M. Sandoval, and N. Aimi :
Two New Nor-triterpene Glycosides from Peruvian "Uña de Gato" (Uncaria tomentosa).
J. Nat. Prod.,66(2), 320-323 (2003).

25. Y. Yamazaki, A. Urano, H. Sudo, M. Kitajima, H. Takayama, M. Yamazaki, N. Aimi, and K. Saito :
Metabolite Profiling of Alkaloids and Strictosidine Synthase Activity in Camptothecin Producing Plants.
Phytochem.,62(3), 461-470 (2003).

26. M. Yokoya, K. Masubuchi, M. Kitajima, H. Takayama, and N. Aimi :
Synthesis and CD measurement of Chiral 1-Ethyl-3-carboxy-1,2,3,4-tetrahydro-b-carbolines: C1 Configuration and Second Sphere Chirality.
Heterocycles,59(2), 521-526 (2003).

27. D. Permana, N. Hj. Lajis, F. Abas, A. G. Othman, R. Ahmad, M. Kitajima, H. Takayama, and N. Aimi :
Antioxidative Constituents of Hedyotis diffusa Willd.
Nat. Prod. Sci.,9(1), 7-9 (2003).

28. Y. Yamazaki, H. Sudo, M. Yamazaki, N. Aimi, and K. Saito :
Camptothecin Biosynthetic Genes in Hairy Roots of Ophiorrhiza pumila: Cloning, Characterization and Differential Expression in Tissues and by Stress Compounds.
Plant and Cell Physiol.,44(4), 395-403 (2003).

29. K. Husain, J. Ibrahim, I. M. Said, N. Aimi, and H. Takayama :
Two New Methyl Chanofruticosinates from Kopsia flavida Blume.
J. Asian Nat. Prod. Res.,5(1), 63-67 (2003).

30. M. Kitajima, N. Kogure, K. Yamaguchi, H. Takayama, and N. Aimi :
Structure Reinvestigation of Gelsemoxonine, a Constituent of Gelsemium elegans, Reveals a Novel, Azetidine-Containing Indole Alkaloid.
Org. Lett.,5(12), 2075-2078 (2003).

31. D. Permana, N. Hj. Lajis, K. Shaari, A. M. Ali, M. M. Mackeen, M. Kitajima, H. Takayama, and N. Aimi :
A. New Prenylated Hydroquinone from the Roots of Garcinia atroviridis Griff ex T. Anders (Guttiferae).
Z. Naturforsch.,58b b, 332-335 (2003).

32. H. Watanabe, Q. Zhao, K. Matsumoto, M. Tohda, Y. Murakami, S.-H. Zhang, T.-Y. Kang, P. Mahakunakorn, Y. Maruyama, I. Sakakibara, N. Aimi, and H. Takayama :
Pharmacological Evidence for Antidementia Effect of Choto-san (Gouteng-san), a Traditional Kampo Medicine.
Pharmacology, Biochemistry and Behavior,75(3), 635-643 (2003).

33. H. Takayama, R. Fujiwara, Y. Kasai, M. Kitajima, and N. Aimi :
First Asymmetric Total Synthesis of Us-7 and -8, Novel D-seco Corynanthe-Type Oxindole Alkaloids from Uncaria attenuata: Structure Revision of Us-7 and Determination of Absolute Stereochemistry.
Organic Lett.,5(16), 2967-2970 (2003).

34. Y. M. Syah, N. S. Aminah, E. H. Hakim, N. Aimi, M. Kitajima, H. Takayama, and S. A. Achmad :
Two Oligostilbenes, cis- and trans-Diptoindonesin B, from Dryobalanops oblongifolia.
Phytochem.,63(8), 913-917 (2003).

35. H. Takayama, K. Katakawa, M. Kitajima, K. Yamaguchi, and N. Aimi :
Ten New Lycopodium Alkaloids Having the Lycopodane Skeleton Isolated from Lycopodium serratum Thunb.
Chem. Pharm. Bull.,51(10), 1163-1169 (2003).

36. M. Kitajima, A. Urano, N. Kogure, H. Takayama, and N. Aimi :
New Oxindole Alkaloids and Iridoid from Carolina jasmine (Gelsemium sempervirens Ait. F.).
Chem. Pharm. Bull.,51(10), 1211-1214 (2003).

37. P. Tiew, H. Takayama, M. Kitajima, N. Aimi, U. Kokpol, and W. Chavasisi :
A Novel Neolignan, Mansoxetane, and Two New Sesquiterpenes, Mansonones R and S, from Mansonia gagei.
Tetrahedron Lett.,44(35), 6759-6761 (2003).

総説・単行書等 Review, Monograph, etc 2002-2003

1. 高山廣光, 相見則郎 : 新しい機能性分子の発見と創製. 千葉大学大学院薬学研究院の成果—薬学の世界をのぞく, 千葉日報 (2002).

2. Hiromitsu Takayama : Current Topics in the Biomimetic Alkaloid Syntheses. J. Synth. Org. Chem., Japan, 60, 350-360 (2002).

3. 高山廣光：未利用薬用資源植物から創薬シード分子を探す. 化学と生物, 40, 676-682 (2002).

原著　Original article 2004-2005

1. H. Takayama, Y. Matsuda, K.Masubuchi, A. Ishida, M. Kitajima, and N. Aimi:
“Isolation, Structure Elucidation, and Total Synthesis of Two New Chimonanthus Alkaloids, Chimonamidine and Chimonanthidine”
Tetrahedron,60(4), 893-900 (2004).

2. Y. Yamazaki, M. Kitajima, M. Arita, H. Takayama, H. Sudo, M. Yamazaki, N. Aimi, and K. Saito:
“Biosynthesis of Camptothecin. In Silico and in Vivo Tracer Study from [1-13C]glucose.”
Plant Physiology,134, 161-170 (2004).

3. K. Matsumoto, S. Horie, H. Ishikawa, H. Takayama, N. Aimi, D. Ponglux, and K. Watanabe:
“Antinociceptive Effect of 7-Hydroxymitragynine in Mice: Discover of an Orally Active Opioid Analgesic from Thai Medicinal Herb Mitragyna speciosa.”
Life Sciences,74(17), 2143-2155 (2004).

4. J. Ogura, M. Mitamura, A. Someya, K. Shimamura, H. Takayama, N. Aimi, S. Horie, and T. Murayama:
“Mesaconitine-induced Relaxation in Rat Aorta: Role of Na+/Ca2+ Exchangers in Endothelial Cells.”
Eur. J. Pharmacol.,483(2-3), 139-146 (2004).

5. J. Ariffin, H. Takayama, M. Kitajima, N. Aimi, and C. Kaneko:
“Density Functional Theory Study of the Preffered Conformation of Geissoschizine.“
Heterocycles,60(3), 663-670 (2004).

6. H. Takayama, H. Ishikawa, M. Kitajima, N. Aimi, and B. M. Aji :
“A New 9-Methoxyyohimbine-Type Alkaloid from Mitragyna africanus.”
Chem. Pharm. Bull.,52(3), 359-361 (2004).

7. K. T. Suzuki, B. K. Mandal, A. Katagiri, Y. Sakuma, A. Kawakami, Y. Ogra, K. Yamaguchi, Y. Sei, K. Yamanaka, K. Anzai, M. Ohmichi, H. Takayama, and N. Aimi :
“Dimethylthioarsenicals as Arsenic Metabolites and Their Chemical Preparations.”
Chem. Res. Toxicol.,17(7), 914-921 (2004).

8. H. Takayama, I. Mori, M. Kitajima, N. Aimi, and N. H. Lajis :
“New Type of Trimeric and Pentameric Indole Alkaloids from Psychotria rostrata.”
Org. Lett.,6(17) 2945-2948 (2004).

9. M. Kitajima, K. Hashimoto, M. Sandoval, N. Aimi, and H. Takayama :
“New Oleanan-Type Triterpene and Cincholic Acid Glycosides from Peruvian “Uña de Gato” (Uncariatomentosa).”
Chem. Pharm. Bull.,52(10), 1258-1261 (2004).

10. H. Ishikawa, M. Kitajima, and H. Takayama :
“m-Chloroperbenzoic Acid Oxidation of Corynanthe-Type Indole Alkaloid, Mitragynine, Afforded Unusual Dimerizaion Products.”
Heterocycles,63(11), 2597-2604 (2004).

11. T.-H. Kang, Y. Murakami, H. Takayama, M. Kitajima, N. Aimi, H. Watanabe, and K. Matsumoto :
“Protective Effect of Rhynchophylline and Isorhynchophylline on in Vitro Ischemia-Induced Neuronal Damage in the Hippocampus: Putative Neurotransmitter Receptors Involved in their Action. “
Life Sciences,76(3), 331-343 (2004).

12. Y. M. Syah, S. A. Achmad, N. Aimi, E. H. Hakim, L. D. Juriawaty, and H. Takayama :“Camptothecin Production by in Vitro Cultures of Ophiorrhiza liukiuensis and O. kuroiwai.”
Plant Biotech.,21(4), 275-281 (2004).

13. R. W. Hakim, A. Nawai, I. Adnyana, S. A. Achmad, L. Makmur, E. H. Hakim, Y. M. Sjah, and M. Kitajima:
“Benzophenone Glucoside from the Red Fruit of Mahkota Dewa Phaleria macrocarpa and its Activity towards DPPH and Murine Leukemia P-388 Cells.”
Bull. Soc. Nat. Prod. Chem. (Indonesia),4(2), 67-70 (2004).

14. E. H. Hakim, Y. M. Syah, N. S. Aminahm M. Kitajima, H. Takayama, and S. A. Achmad :
“Regioselective Glycosylation of Oxyresveratrol in Cell Suspension Culture of Solanum mamosum.”
J. Chem. Res., (10) 706-707 (2004).

15. S. A. Achmad, N. A. Emilo, L. Ghisalberti, E. H. Hakim, M. Kitajima, L. Makmur, D. Mujahidin, Y. M. Syah, and H. Takayama :
“Molecular Diversity and Biological Activity of Natural Products from Indonesian Moraceous Plants.”
J. Chem. Soc. Pakistan,26(3), 316-321 (2004).

16. K. Katakawa, M. Kitajima, N. Aimi, H. Seki, K. Yamaguchi, K. Furihata, T. Harayama, and H. Takayama :
“Structure Elucidation and Synthesis of Lycoposerramine-B, a Novel Oxime-Containing Lycopodium Alkaloid from Lycopodium serratum Thunb.”
J. Org. Chem.,70(2), 658-663 (2005).

17. H. Yusof, F. Ahmad, H. Takayama, and L. B. Din:
“Alkaloids from the Leaves of Gelsemium elegans (Loganiacee).”
Malaysian Journal of Science,24, 37-39 (2005).

18. Y. Matsuda, M. Kitajima, and H. Takayama :
“Total Synthesis and Structure Reinvestigation of So-called Isochimonanthine.”
Heterocycles,65(5), 1031-1033 (2005).

19. P. Leewanich, M. Tohda, H. Takayama, S. Sophasan, H. Watanabe, and K. Matsumoto :
“Corymine Potentiates NMDA-induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors.”
J. pharmacolo. Sci.,98(1), 58-65 (2005).

20. H. Takayama, R. Sudo, and M. Kitajima :
“Determination of Absolute Configuration of Pandanus Alkaloid, Pandamarilactonine-A, by First Asymmetric Total Synthesis.”
Tetrahedron Lett.,46(35), 5795-5797 (2005).

21. N. Kogure, C. Nishiya, M. Kitajima, and H. Takayama :
“Six New Indole Alkaloids from Gelsemium sempervirens Ait. f.”
Tetrahedron Lett.,46(35), 5857-5861 (2005).

22. K. Matsumoto, R. Morishige, Y. Murakami, M. Tohda, H. Takayama, and I. Sakakibara , H. Watanabe :
“Suppressive Effects of Isorhynchophylline on 5-HT2A Receptor Function in the Brain: Behavioural and Electrophysiological Studies.”
Eur. J. Pharmacolo.,517(3), 191-199 (2005).

23. M. Kitajima, N. Fujii, F. Yoshino, H. Sudo, K. Saito, N. Aimi, and H. Takayama :
“Camptothecins and Two New Monoterpene Glucosides from Ophiorrhiza liukiuensis.”
Chem. Pharm. Bull.,53(10), 1355-1358 (2005).

24. S. Horie, F. Koyama, H. Takayama, H. Ishikawa, N. Aimi, D. Ponglux, K. Matsumoto, and T. Murayama :
“ Indole Alkaloids of a Thai Medicinal Herb, Mitragyna speciosa, that Has Opioid Agonistic Effect in Guinea-pig ileum.”
Planta Med.,71(3), 231-236 (2005).

25. K. Matsumoto, S. Horie, H. Takayama, H. Ishikawa, N. Aimi, D. Ponglux, T. Murayama, and K. Watanabe :
“Antinociception, Tolerance and Withdrawal Symptoms Induced by 7-Hydroxymitragynine, an Alkaloid from the Thai Medicinal Herb Mitragyna speciosa.”
Life sci.,78(1), 2-7 (2005).

26. K. Matsumoto, L. T. Yamamoto, K. Watanabe, S. Yano, J. Shan, P. K. T. Pang, D. Ponglux, H. Takayama, and S. Horie :
“Inhibitory Effect of Mitragynine, an Analgesic Alkaloid from Thai Herbal Medicine, on Neurogenic Contraction of the Vas Deferens.”
Life sci.,78(2), 187-194 (2005).

27. C. Niampoka, R. Suttisri, R. Bavovada, H. Takayama, and N. Aimi :
“Potentially Cytotoxic Triterpenoids from the Root Bark of Siphonodo celastrineus Griff.”
Arch. Pharm. Res.,28(5), 546-549 (2005).

28. R. Ahmad, K. Shaari, N. Hj. Lajis, A. S. Hamzah, N. H. Ismail, M. Kitajima:
“Anthraquinones from Hedyotis capitellata.”
Phytochem.,66(10), 1141-1147 (2005).

総説Review 2004-2005

1.H. Takayama :
“ Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa.”
Chem. Pharm. Bull.,52(8), 916-928 (2004).

2. H. Takayama, M. Kitajima, and N. Kogure :
“ Chemistry of Corynanthe-Type Related Indole Alkaloids from the Uncaria, Nauclea, and Mitragyna Plants.”
Current Organic Chemistry,9(15), 1445-1464 (2005).