研究業績
2024
Original Article
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K. Yamanishi, G. Ashihara, S. Shiomi, S. Harada*, M. Kitajima, H. Takayama, H. Ishikawa*
New Entries in Organocatalysts from an Alkaloid Library; Development of Aminal Catalysis for a Michael Reaction Based on Calycanthine
J. Am. Chem. Soc. , 146, 27152-27160 (2024).
千葉大学 “プレスリリース”
蝋梅（ロウバイ）の種子から新しい作用機構をもつ不斉有機触媒を発見－千葉大学天然物ライブラリーの活用と化学的応用－
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G. Yoshimura, J. Sakamoto, M. Kitajima, H. Ishikawa*
Indole C5-Selective Bromination of Indolo[2,3-a]quinolizidine Alkaloids via In Situ-Generated Indoline Intermediate
Chem. Eur. J. , 30, e202401153 (2024).
Selected “Hot Paper”
Selected “Cover picture”
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S. Imaoka‡, Y. Nakashima‡, M. Kitajima, H. Ishikawa*
‡These authors contributed equally.
Bioinspired Total Synthesis of (+)-Kopsiyunnanine B
Chem. Pharm. Bull., 72, 68-74 (2024).
Invited Article
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J. Sakamoto‡, D. Hiruma‡, M. Kitajima, H. Ishikawa*
‡These authors contributed equally.
Collective Total synthesis of β-Carboline-type Monoterpenoid Indole Alkaloid Glycosides
Synlett, 35(5), 576-581 (2024).
Invited article as a special cluster "biomimetic synthesis".
Review and Book Chapter
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Y. Nakashima, K. Rakumitsu, H. Ishikawa*
Recent advances in the total synthesis of alkaloids using chiral secondary amine organocatalysts.
Org. Biomol. Chem. , 22, 9319-9341 (2024).
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J. Sakamoto, H. Ishikawa*
Collective Synthesis of Secologanin-Related Natural Products.
Modern Natural Product Synthesis, Springer, Singapore, edited by Masahisa Nakada, Keiji Tanino, Kazuo Nagasawa, Satoshi Yokoshima eds., (2024).
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石川勇人*
天然物全合成のためのテーラーメード有機触媒反応の開発
有機合成化学協会誌（Journal of Synthetic Organic Chemistry, Japan）, 82, 473–482 (2024).
2023
Original Article
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Mario A. Tan*, H. Ishikawa
Constituents of Uncaria lanosa f. philippinensis and their anti-amyloidogenic activity
Nat. Prod. Res (2023). Published on the web.
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Y. Ito, H. Lu, M. Kitajima, H. Ishikawa, Y. Nakata, Y. Iwatani, T Hoshino*
Sticklac-Derived Natural Compounds Inhibiting RNase H Activity of HIV-1 Reverse Transcriptase
J. Nat. Prod., 86, 2487-2495 (2023).
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Y. Ataka, M. Kitajima, H. Ishikawa*
Enantioselective Total Syntheses of (–)-Silicine and (–)-20-Episilicine
Org. Lett., 25, 7601-7605 (2023).
Selected “Front Cover”
Highlighted in SYNFACTS
Highlighted by Organic Chemistry Portal
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Y. Nakashima, T. Inoshita, M. Kitajima, H. Ishikawa*
Asymmetric Total Synthesis of Senepodine F
Org. Lett., 25, 1151-1155 (2023).
Highlighted by Organic Chemistry Portal
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J. Sakamoto, M. Kitajima, H. Ishikawa*
Total Syntheses of (+)-Villocarine A, (–)-Apogeissoschizine, and (+)-Geissoschizine
Chem. Eur. J., e202300179 (2023).
Selected “Cover Picture”
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A. Yoshidome, J. Sakamoto, M. Kohara, S. Shiomi, M. Hokaguchi, Y. Hitora, M. Kitajima, S. Tsukamoto, H. Ishikawa*
Divergent Total Syntheses of Hetero-Oligomeric Iridoid Glycosides
Org. Lett., 25, 347-352 (2023).
Highlighted in SYNFACTS
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M. Oota, S. Toyoda, T. Kotake, N. Wada, M. Hashiguchi, R. Akashi, H. Ishikawa, B. Favery, A. Y.-L. Tsai, S. Sawa*
Rhamnogalacturonan-I as a nematode chemoattractant from Lotus corniculatus L. Supergrowing Root culture
Front. Plant Sci., 13 (2023).
Review and Book Chapter
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J. Sakamoto, H. Ishikawa*
Bioinspired Total Syntheses of Secologanin-Related Natural Products; Demonstration of the Power of Secologanin in the Flask
Synlett, 34(19), 2293-2303 (2023).
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H. Ishikawa*
New Tide of Natural Product Chemistry, Springer, Singapore, edited by Hayato Ishikawa, Hiromitsu Takayama eds. 2023,
Chapter 10; Collective Synthesis of Monoterpenoid Indole Alkaloids Using Bioinspired Strategies.
https://doi.org/10.1007/978-981-99-1714-3_10
2022
Original Article
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J. Wang, H. Suzuki, N. Nakashima, M. Kitajima, H. Takayama, K. Saito, M. Yamazaki, N. Yoshimoto*
Identification of a Regiospecific S-Oxygenase for the Production of Marasmin in Traditional Medicinal Plant Tulbaghia violacea.
Plant Biotechnology, 39, 281–289 (2022).
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M. A. Tan*, H. Ishikawa, S. S. A. An*
Pandanus amaryllifolius Exhibits In Vitro Anti-Amyloidogenic Activity and Promotes Neuroprotective Effects in Amyloid-β-Induced SH-SY5Y Cells
Nutrients, 14, 3962 (2022).
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J. Sakamoto, M. Kitajima, H. Ishikawa*
Asymmetric Total Syntheses of Mitragynine, Speciogynine, and 7-Hydroxymitragynine
Chem. Pharm. Bull., 70, 662-668 (2022).
Selected “Featured Article”
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N. Nakashima, J. Sakamoto, K. Rakumitsu, M. Kitajima, L. D. Juliawaty, H. Ishikawa*
Secorubenine, a Monoterpenoid Indole Alkaloid Glycoside from Adina rubescens: Isolation, Structure Elucidation, and Enantioselective Total Synthesis
Chem. Pharm. Bull., 70, 187-191 (2022).
Selected “Featured Article”
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K. Urakawa, Y. Yatsuoka, Y. Kawabata, H. Masu, M. Matsuda*, H. Ishikawa*
Borocyclic Radicals Prepared from Orthoquinone-Containing Polycyclic Aromatics by Photoirradiation
J. Org. Chem., 87, 3747-3751 (2022).
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S. Shiomi, K. Wilailak, W. Soutome, H. Takayama, M. Kitajima, H. Ishikawa*
Asymmetric Total Synthesis and Structure Elucidation of Huperzine H
J. Org. Chem., 87, 3730-3735 (2022).
Selected “Cover Picture”
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J. Sakamoto, H. Ishikawa*
Bioinspired Transformations Using Strictosidine Aglycones: Divergent Total Syntheses of Monoterpenoid Indole Alkaloids in the Early Stage of Biosynthesis
Chem. Eur. J., 28, e202104052 (2022).
Selected “Inside Cover Picture”
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A. Saito, C. Fujita, N. Kogure, N. T. Vung, L. A. Hao, H. Takayama, M. Kitajima*
New monoterpenoid indole alkaloids from Gelsemium elegans seeds
Tetrahedron, 104, 132572 (2022).
Selected as “2022 Editor's Choice Collection” and “Front Cover”
Review and Book Chapter
2021
Original Article
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Y. Maeyama, Y. Nakashima, H. Kato, Y. Hitora, K. Maki, N. Inada, S. Murakami, T. Inazumi, Y. Ise, Y. Sugimoto, H. Ishikawa, and S. Tsukamoto*
Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts
J. Nat. Prod., 84, 2738-2743 (2021).
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AY. Tsai, Y. Iwamoto, Y. Tsumuraya, M. Oota, T. Konishi, S. Ito, T. Kotake, H. Ishikawa and S. Sawa*
Root-Knot nematode chemotaxis is positively regulated by L-garactose sidechains of mucilage carcohydrate rhamnogalacturonan-Ⅰ
Sci. Adv., 7, eabh4182 (2021).
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S. Toyoda, M. Oota, H. Ishikawa, S. Sawa*
Calcium Sulfate and Calcium Carbonate as Root-Knot-Nematode Attractants and Possible Trap Materials to Protect Crop Plants
Plant Biotechnology, 38, 157–159 (2021).
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T. Ishida*, H. Yoshimura, M. Takekawa, T. Higaki, T. Ideue, M. Hatano, M. Igarashi, T. Tani, S. Sawa, H. Ishikawa*
Discovery, Characterization and Functional Improvement of Kumamonamide as a Novel Plant Growth Inhibitor that Disturb Plant Microtubules
Sci. Rep., 11, 6077 (2021).
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T. Onozawa, N. Kogure, H. Takayama, and M. Kitajima:
Elucidation of Absolute Configuration of Ophiorrhiside A by Comparison of ECD Spectra with That of Model Chiral Compound Having a 1,2,3,4-Tetrahydro-β-carbolin-3-on Skeleton.
Heterocycles, 102(1), 35-43 (2021).
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E. Hermawati*, S. D. Ellita, L. D. Juliawaty, E. H. Hakim, Y. M. Syah, H. Ishikawa
Epoxyquinophomopsins A and B from Endophytic Fungus Phomopsis sp. and Their Activity against Tyrosine Kinase
J. Nat. Med. 75, 217–222 (2021).
Review and Book Chapter
2020
Original Article
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H. Sugama, T. Matsudaira, H. Yanagisawa, R. Ohashi, M. Nawano, K. Yasuda, and H. Takayama
Design, Synthesis, and Pharmacological Evaluation of 2-(4-Sulfonylphenyl)-2-[(E)-pyrrolidin-1- ylimino]-N-thiazoleacetamides as Glucokinase Activators.
Bioorg. Med. Chem. Lett., 30(15), 127249 (2020).
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J. Sakamoto, Y. Umeda, K. Rakumitsu, M. Sumimoto,H. Ishikawa*
Total Syntheses of (–)-Strictosidine and Related Indole Alkaloid Glycosides
Angew. Chem. Int. Ed., 59, 13414–13422 (2020).
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L. D. Juliawaty*, P. N. Ra’idah, S. Abdurrahman, E. Hermawati, A. Alni, M. I. Tan, H. Ishikawa, Y. M. Syah
5,6-Dihydro-α-pyrones from the Leaves of Cryptocarya pulchinervia (Lauraceae)
J. Nat. Med. 74, 584–590 (2020).
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M. Matsumoto, K. Wada, K. Urakawa, H. Ishikawa*
Diaryliodonium Salt-Mediated Intramolecular C–N Bond Formation Using Boron-Masking N-Hydroxyamides.
Org. Lett., 22, 781–785 (2020).
Selected “Cover Picture”
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M. Oota, A. Y.-L. Tsai, D. Aoki, Y. Matsushita, S. Toyoda, K. Fukushima, K. Saeki, K. Toda, L. Perfus-Barbeoch, B. Favery, H. Ishikawa*, S. Sawa*
Identification of Naturally-Occurring Polyamines as Nematode Meloidogyne incognita Attractants
Mol. Plant 13, 658–665 (2020).
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D. Ito, D. Ge, N. Kogure, H. Manaka, Y. Terui, H. Takayama, R. J. Linhardt, T. Toida, K. Higashi
Poly-ion complex (PIC) Formation of Heparin and Polyamines: PIC with Tetrakis(3-aminopropyl)ammonium Allows Sustained Release of Heparin
Heliyon 6, e05168 (2020).
