logo千葉大学大学院薬学研究院薬品物理化学研究室

Publications

    2018年以前の薬品物理化学教室の業績はこちら

2024年

  • Zhao Q, Shimada I*, Nishida N* Real-Time Monitoring of RAS Activity Using In Vitro and In-Cell NMR Spectroscopy Methods Mol Biol. 2797:237-252 (2024)
  • Watanabe K#, Zhao Q#, Iwatsuki R, Fukui R, Ren W, Sugita Y*, Nishida N* Deciphering the Multi-state Conformational Equilibrium of HDM2 in the Regulation of p53 Binding: Perspectives from Molecular Dynamics Simulation and NMR Analysis J Am Chem Soc. 146(14):9790-9800 (2024)

2023年

  • Zhao Q, Haga R, Tamura S, Shimada I*, Nishida N* Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy Sci Rep 13, 19253 (2023)
  • Nishide G, Lim K, Tamura M, Kobayashi A, Zhao Q, Hazawa M, Ando T, Nishida N*, Wong RW* Nanoscopic Elucidation of Spontaneous Self-Assembly of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Open Reading Frame 6 (ORF6) Protein J Phys Chem Lett. 14(38):8385-8396 (2023)
  • 外山侑樹、西田紀貴、嶋田一夫　「RAC1発がん性変異体の動的分子機構」　月刊「細胞」 55、136-139 (2023)

2022年

  • 西田紀貴　「In-cell NMR法を用いた細胞内生命現象のリアルタイム観測」日本核磁気共鳴学会機関紙, 12, 17-22 (2022)

2021年

  • Qu L, Qiao X, Qi F, Nishida N, Hoshino T.* Analysis of Binding Modes of Antigen-Antibody Complexes by Molecular Mechanics Calculation J Chem Inf Model. 2021 61(9):4571-4581 (2021)
  • Guo Y, Qu L, Nishida N, Hoshino T* Electrostatic Potentials around the Proteins Preferably Crystallized by Ammonium Sulfate Crystal Growth & Design 21, 297-305 (2021)
  • 西田紀貴　「バイオリアクター型in-cell NMR法の開発とRasの活性状態の観測への応用」生化学 93, 819-823 (2021)
  • 4. 趙慶慈、嶋田一夫、西田紀貴　「分子夾雑系が変調するタンパク質の構造と機能」月刊「細胞」 53, 352-355 (2021)

2020年

  • Zhao Q, Fujimiya R, Kubo S, Marshall CB, Ikura M, Shimada I*, Nishida N*. Real-time In-cell NMR Reveals the Intracellular Modulation of GTP-bound Levels of RAS. Cell Rep. 32, 108074 (2020)　→プレスリリース（千葉大学）
  • Nishida N, Komori Y, Takarada O, Kubo S, Tamura S, Shimada I*, Kikkawa M*. Structural basis for two-way communication between dynein and microtubules. Nat Commun. 11, 1038 (2020)
  • Nishida N, Ito Y*, Shimada I*. in situ structural biology by in-cell NMR. Biochim Biophys Acta Gen Subj. 1864(2):129421 (2020)
  • Nishida N, Tsukazaki T, Kohda D*. Preface to the special issue on novel measurement techniques for visualizing 'live' protein molecules at work. Biochim Biophys Acta Gen Subj. 1864(2):129364 (2020).

2019年

  • 西田紀貴、嶋田一夫「夾雑系の構造生物学」　化学と工業　72, 404-406 (2019)

2018年以前（selected）

  • Mochizuki A, Saso A, Zhao Q, Kubo S, *Nishida N, *Shimada I., Balanced Regulation of Redox Status of Intracellular Thioredoxin Revealed by in-Cell NMR. J Am Chem Soc. 140:3784-3790 (2018) (selected as Spotlight)
  • Huang S, Umemoto R, Tamura Y, Kofuku Y, Uyeda TQ, Nishida N, Shimada I*. “Utilization of paramagnetic relaxation enhancements for structural analysis of actin-binding proteins in complex with actin.” Sci Rep. 6, 33690, (2016)
  • Suzuki T, Suzuki S, Umemoto R, Ogino S, Nishida N, Shimada I*, “Mechanical force effect on the two-state equilibrium of the hyaluronan-binding domain of CD44 in cell rolling” Proc Natl Acad Sci U S A., 112, 6991-6 (2015)
  • Kubo S, Nishida N, Udagawa Y, Takarada O, Ogino S, Shimada I, “A gel-encapsulated bioreactor system for NMR studies of protein-protein interactions in living mammalian cells.”Angew Chem Int Ed. 52, 1208-11 (2013)
  • Ogino S, Nishida N, Umemoto R, Suzuki M, Takeda M, Terasawa H, Kitayama J, Matsumoto M, Hayasaka H, Miyasaka M, Shimada I “Two-state conformations in the hyarulonan-binding domain regulate CD44 adhesiveness under flow condition” Structure, 18, 649-56 (2010)
  • Ogino S, Kubo S, Umemoto R, Huang S, Nishida N, Shimada I “Observation of NMR signals from proteins introduced into living mammalian cells by reversible membrane permeabilization using a pore-forming toxin, Streptolysin O” J Am Chem Soc, 131, 10834-5 (2009)
  • Zhu J, Luo BH, Xiao T, Zhang C, Nishida N, Springer TA. “Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces” Mol Cell 32, 849-61 (2008)
  • Nishida N, Walz T, Springer TA “Structural transitions of complement component C3 and its activation products” Proc. Natl. Acad. Sci USA 103, 19737-19742 (2006)
  • Nishida N, Xie C, Shimaoka M, Cheng Y, Walz T, Springer TA “Activation of leukocyte beta2 integrins by conversion from bent to extended conformations” Immunity 25, 583-594 (2006)
  • Nishida N, Sumikawa H, Sakakura M, Shimba N, Takahashi H, Terasawa H, Suzuki E, Shimada, I. “Collagen binding mode of vWF-A3 domain determined by a transferred cross-saturation experiment” Nature Struct Biol 10, 53-57 (2003)
PAGE TOP