2024
Yoshikawa, E., Ueda, K., Hakata, R., Higashi, K., Moribe, K.: Quantitative investigation of intestinal drug absorption enhancement by drug-rich nanodroplets generated via liquid–liquid phase separation. Mol. Pharm., 21 (4), 1745-1755 (2024). https://doi.org/10.1021/acs.molpharmaceut.3c01078
Sunazuka, Y., Ueda, K., Higashi, K., Wada, K., Moribe, K.: Mechanistic analysis of temperature-dependent curcumin release from poly(lactic-co-glycolic acid)/poly(lactic acid) polymer nanoparticles. Mol. Pharm., 21(3), 1424-1435 (2024). https://doi.org/10.1021/acs.molpharmaceut.3c01066
Anindita, J., Tanaka, H., Yamakawa, T., Sato, Y., Matsumoto, C., Ishizaki, K., Oyama, T., Suzuki, S., Ueda, K., Higashi, K., Moribe, K., Sasaki, K., Ogura, Y., Yonemochi, E., Sakurai, Y., Hatakeyama, H., Akita, H.: The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles. Pharmacuetics, 16(2), 181 (2024). https://doi.org/10.3390/pharmaceutics16020181
2023
Ueda, K., Sakagawa, Y., Saito, T., Fujimoto, T., Nakamura, M., Sakuma, F., Kaneko, S., Tokumoto, T., Nishimura, K., Takeda, J., Arai, Y., Yamamoto, K., Ikeda, Y., Higashi, K., Moribe, K.: Molecular-level structural analysis of siRNA-loaded lipid nanoparticles by 1H NMR relaxometry: Impact of lipid composition on their structural properties. Mol. Pharm., 20(9), 4729-4742 (2023). https://doi.org/10.1021/acs.molpharmaceut.3c00477
Miyazaki, T., Mizoguchi, R., Ueda, K., Shinozaki, T., Kamoto, M., Takeda, Y., Sakuma, S., Ito, N., Momo, M., Kawakami, K.: Crystallization of amorphous nifedipine under isothermal conditions: Inter-laboratory reproducibility and investigation of the factors affecting reproducibility. J. Pharm. Sci., 112(10), 2703-2716 (2023). https://doi.org/10.1016/j.xphs.2023.06.002
Kadota, K., Kämäräinen, T., Sakuma, F., Ueda, K., Higashi, K., Moribe, K., Uchiyama, H., Minoura, K., Tozuka, Y.: Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses. Food. Funct., 14, 10493-10505 (2023). https://doi.org/10.1039/D3FO03261B
Hanada, N., Higashi, K., Zhao, Z., Ueda, K., Moribe, K.: Preparation of a ternary amorphous solid dispersion using hot-melt extrusion for obtaining a stable colloidal dispersion of amorphous probucol nanoparticles. Int. J. Pharm., 640, 122959 (2023). https://doi.org/10.1016/j.ijpharm.2023.122959
Kundu, S., Higashi, K., Takamizawa, M., Ueda, K., Moribe, K.: Vapor-phase-mediated encapsulation of guest drug molecules in the hexagonal columnar form structure of polyethylene glycol/γ-cyclodextrin-polypseudorotaxane. Cryst. Growth. Des., 23(8), 6119-6129 (2023). https://doi.org/10.1021/acs.cgd.3c00619
Hatanaka, Y., Uchiyama, H., Kaneko, S., Ueda, K., Higashi, K., Moribe, K., Furukawa, S., Takase, M., Yamanaka, S., Kadota, K., Tozuka, Y.: Designing a novel coamorphous salt formulation of telmisartan with amlodipine to enhance permeability and oral absorption. Mol. Pharm., 20(8), 4071-4085 (2023). https://doi.org/10.1021/acs.molpharmaceut.3c00226
Chen, Z., Higashi, K., Shigehisa, Y., Ueda, K., Yamamoto, K., Moribe, K.: Understanding the rod-to-tube transformation of self-assembled ascorbyl dipalmitate lipid nanoparticles stabilized with PEGylated lipids. Nanoscale, 15, 2602-2613 (2023). https://doi.org/10.1039/D2NR04987B
Hohokabe, M., Higashi, K., Yamada, Y., Fujimoto, T., Tokumoto, T., Imamura, H., Morita, T., Ueda, K., Limwikrant, W., Moribe, K.: Modification of liposomes composed of a cationic lipid TMAG and an anionic lipid DSPG with a PEGylated lipid based on the investigation of lipid structures. Colloid. Surf. A: Phys. Eng. Asp., 661, 130981 (2023). https://doi.org/10.1016/j.colsurfa.2022.130891
Liu, M., Higashi, K., Ueda, K., Moribe, K.: Supersaturation maintenance of carvedilol and chlorthalidone by cyclodextrin derivatives: Pronounced crystallization inhibition ability of methylated cyclodextrin. Int. J. Pharm., 637, 122876 (2023). https://doi.org/10.1016/j.ijpharm.2023.122876
Tanaka, H., Hagiwara, S., Shirane, D., Yamakawa, T., Sato, Y., Matsumoto, C., Ishizaki, K., Hishinuma, M., Chida, K., Sasaki, K., Yonemochi, E., Ueda, K., Higashi, K., Moribe, K., Tadokoro, T., Maenaka, K., Taneichi, S., Nakai, Y., Tange, K., Sakurai, Y., Akita, H.: Ready-to-use-type lyophilized lipid nanoparticle formulation for the postencapsulation of messenger RNA. ACS Nano, 17(3), 2588-2601 (2023). https://doi.org/10.1021/acsnano.2c10501
Ueda, K., Higashi, K., Moribe, K.: Quantitative analysis of drug supersaturation region by temperature-variable nuclear magnetic resonance measurements, part 1: Effects of polymer and drug chiralities. Mol. Pharm., 20(4), 1861-1871 (2023). https://doi.org/10.1021/acs.molpharmaceut.2c00924
Ueda, K., Higashi, K., Moribe, K.: Quantitative analysis of drug supersaturation region by temperature-variable nuclear magnetic resonance measurements, part 2: Effects of solubilizer. Mol. Pharm., 20(4), 1872-1883 (2023). https://doi.org/10.1021/acs.molpharmaceut.3c00050
2022
Ma, X., Higashi, K., Fukuzawa, K., Ueda, K., Kadota, K., Tozuka, Y., Yonemochi, E., Moribe, K.: Computational approach to elucidate the formation and stabilization mechanism of amorphous formulation using molecular dynamics simulation and fragment molecular orbital calculation. Int. J. Pharm., 615(5), 121477 (2022). https://doi.org/10.1016/j.ijpharm.2022.121477
Ueda, K., Yamamoto, N., Higashi, K., Moribe, K.: NMR-based mechanistic study of crystal nucleation inhibition in a supersaturated drug solution by polyvinylpyrrolidone. Cryst. Growth. Des., 22(5), 3535-3544 (2022). https://doi.org/10.1021/acs.cgd.2c00084
Sodalee, K., Limwikrant, W., Pongjanyakul, T., Ueda, K., Higashi, K., Moribe, K., Puttipipatkhachorn, S.: Preparation of redispersible dry nanoemulsion using chitosan-octenyl succinic anhydride starch polyelectrolyte complex as stabilizer. J. Drug. Deliv. Sci. Technol., 73, 103433 (2022). https://doi.org/10.1016/j.jddst.2022.103433
Taharabaru, T., Kihara, T., Onodera, R., Kogo, T., Higashi, K., Moribe, K., Nakamura, T., Motoyama, K., Higashi, T.: Polyrotaxane-based multi-step transformable materials for the delivery of Cas9 ribonucleoprotein. Appl. Mater. Today, 27, 101488 (2022). https://doi.org/10.1016/j.apmt.2022.101488
Chen, Z., Higashi, K., Ueda, K., Moribe, K.: Multistep crystallization of pharmaceutical amorphous nanoparticles via a cognate pathway of oriented attachment: Direct evidence of nonclassical crystallization for organic molecules. Nano. Lett., 22(16), 6841-6846 (2022). https://doi.org/10.1021/acs.nanolett.2c01608
Ueda, K., Higashi, K., Moribe, K.: Unusual correlation between the apparent amorphous solubility of a drug and solubilizer concentration revealed by NMR analysis. Mol. Pharm., 19(9), 3336-3349 (2022). https://doi.org/10.1021/acs.molpharmaceut.2c00478
Ishimoto, A., Sasako, H., Omori, M., Higashi, K., Ueda, K., Koyama, K., Moribe, K.: Drug-loaded nanocarriers composed of cholesteryl oleate crystal cores and multiple-nanosheet shells of γ-cyclodextrin inclusion complex crystals. Langmuir, 38(34), 10454-10464 (2022). https://doi.org/10.1021/acs.langmuir.2c01199
Morita, T., Okada, H., Yamada, T., Hidaka, R., Ueki, T., Niitsuma, K., Kitazawa, Y., Watanabe, M., Nishikawa, K., Higashi, K.: A study combining magic-angle spinning NMR and small-angle X-ray scattering on the interaction in the mixture of poly(benzyl methacrylate) and ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethanesulfonyl)amide. Phys. Chem. Chem. Phys., 24, 26575-26582 (2022). https://doi.org/10.1039/D2CP02207A
Yamaguchi, M., Kanazawa, T., Morino, S., Iioka, S., Watanabe, Y., Dohi, N., Higashi, K., Kondo, H., Ishikawa, T.: Increased tropism of extracellular vesicles derived from palmitic acid-treated hepatocytes to activated hepatic stellate cells. Membranes, 12(10), 1023 (2022). https://doi.org/10.3390/membranes12101023
Ueda, K., Higashi, K., Moribe, K., Taylor, L.S. : Variable-temperature NMR analysis of the thermodynamics of polymer partitioning between aqueous and drug-rich phases and its significance for amorphous formulations. Mol. Pharm., 19(1), 100-114 (2022). https://doi.org/10.1021/acs.molpharmaceut.1c00664
Chen, Z., Higashi, K., Ueda, K., Moribe, K.: Transition from amorphous cyclosporin A nanoparticles to size-reduced stable nanocrystals in a poloxamer 407 solution. Mol. Pharm., 19(1), 188-199 (2022). https://doi.org/10.1021/acs.molpharmaceut.1c00721
Fujito, T., Oshima, T., Higashi, K., Ueda, K., Ito, M., Masu, H., Noguchi, S., Moribe, K.: Salt cocrystallization of loxoprofen sodium with sugar: Reduction of the propensity for hydrate formation by forming a continuous one-dimensional chain structure of sodium and sugar. Cryst. Growth. Des., 22(2), 1094-1103 (2022). https://doi.org/10.1021/acs.cgd.1c01050
Sasako, H., Koyama, K., Higashi, H., Ueda, K., Ishimoto, A., Moribe, K.: Enteric complex layer-coated controlled release of capsaicin from phytosterol/γ-cyclodextrin microparticles via guest exchange reaction with taurocholic acid. Eur. J. Pharm. Sci., 168, 106038 (2022). https://doi.org/10.1016/j.ejps.2021.106038
Correa, Soto, C. E., Gao, Y., Indulkar, A. S., Ueda, K., Zhang, G. G., Taylor, L. S.: Impact of surfactants on the performance of clopidogrel-copovidone amorphous solid dispersions: Increased drug loading and stabilization of nanodroplets.. Pharm. Res., 39(1), 167-188 (2022). https://doi.org/10.1007/s11095-021-03159-w
2021
Morikawa, C., Ueda, K., Omori, M., Higashi, K., Moribe, K.: Formation mechanism of amorphous drug nanoparticles using the antisolvent precipitation method elucidated by varying the preparation temperature. Int. J. Pharm., 610, 121210 (2021). https://doi.org/10.1016/j.ijpharm.2021.121210
Okamoto, Y., Higashi, K., Morita, T., Ueda, K., Mukaide, S., Takeda, J., Karashima, M., Ikeda, Y., Moribe, K.: Nanostructure and molecular-level characterization of aminoalkyl methacrylate copolymer and the impact on drug solubilization ability. Mol. Pharm., 18(11), 4111-4121 (2021). https://doi.org/10.1021/acs.molpharmaceut.1c00526
Zhao, Z., Higashi, K., Ueda, K., Moribe, K.: Revealing the mechanism of morphological variation of amorphous drug nanoparticles formed by aqueous dispersion of ternary solid dispersion. Int. J. Pharm., 607, 120984 (2021). https://doi.org/10.1016/j.ijpharm.2021.120984
Morita, T., Mukaide, S., Chen, Z., Higashi, K., Imamura, H., Moribe, K., Sumi, T.:: Unveiling the interaction potential surface between drug-entrapped polymeric micelles clarifying the high drug nanocarrier efficiency. Nano. Lett., 21(3), 1303-1310 (2021). https://doi.org/10.1021/acs.nanolett.0c03978
Ueda, K., Taylor, L. S. : Partitioning of surfactant into drug-rich nanodroplets and its impact on drug thermodynamic activity and droplet size. J. Control. Release, 330, 229-243 (2021). https://doi.org/10.1016/j.jconrel.2020.12.018
Ueda, K., Moseson, D. E., Pathak, V., Taylor, L. S.: Effect of Polymer Species on Maximum Aqueous Phase Supersaturation Revealed by Quantitative Nuclear Magnetic Resonance Spectroscopy. Mol. Pharm., 18(3), 1344-1355 (2021). https://doi.org/10.1021/acs.molpharmaceut.0c01174
Budiman, A., Higashi, K., Ueda, K., Moribe, K.: Effect of drug-coformer interactions on drug dissolution from a coamorphous in mesoporous silica. Int. J. Pharm., 600, 120492 (2021). https://doi.org/10.1016/j.ijpharm.2021.120492
Aoki,C., Ma, Xiaohan., Higashi, K., Ishizuka, Y., Ueda, K., Kadota, K., Fukuzawa, K., Tozuka, Y., Kawakami, K., Yonemochi, E., Moribe, K.: Stabilization mechanism of amorphous carbamazepine by transglycosylated rutin, a non-polymeric amorphous additive with a high glass transition temperature. Int. J. Pharm., 600, 120491 (2021). https://doi.org/10.1016/j.ijpharm.2021.120491
Chen, Z., Higashi, K., Shidara, R., Ueda, K., Morita, T., Limwikrant, W., Yamamoto, K., Moribe, K.: The nanostructure of rod-like ascorbyl dipalmitate nanoparticles stabilized by a small amount of DSPE-PEG. Int. J. Pharm., 602, 120599 (2021). https://doi.org/10.1016/j.ijpharm.2021.120599
Ueda, K., Higashi, K., Moribe, K.: Amorphous drug solubility and maximum free drug concentrations in cyclodextrin solutions: A quantitative study using NMR diffusometry. Mol. Pharm., 18(7), 2764-2776 (2021). https://doi.org/10.1021/acs.molpharmaceut.1c00311
2020
Supasena, W., Muangnoi,C., Thaweesest, W., Songkram,C., Ueda, K., Higashi, K., Moribe, K.,Tanasupawat, S., Rojsitthisak, P.: Enhanced antipsoriatic activity of mycophenolic acid against the TNF-α-induced HaCaT cell proliferation by conjugated poloxamer micelles. J. Pharm. Sci. , 109(2), 1153-1160 (2020). https://doi.org/10.1016/j.xphs.2019.11.010
Okada, H., Ueda, K., Yasuda, Y., Higashi, K., Inoue, M., Masataka, Ito., Noguchi, S., Kawakami, K., Moribe, K.: Correlation between drug dissolution and resistance to water-induced phase separation in solid dispersion formulations revealed by solid-state NMR spectroscopy. Int. J. Pharm., 577, 119086 (2020). https://doi.org/10.1016/j.ijpharm.2020.119086
Ueda, K., Taylor, L. S. : Polymer type impacts amorphous solubility and drug-rich phase colloidal stability: A mechanistic study using nuclear magnetic resonance spectroscopy. Mol. Pharm., 17(4), 1352-1362 (2020). https://doi.org/10.1021/acs.molpharmaceut.0c00061
Hens, B., Kataoka, M., Ueda, K., Gao, P., Tsume, Y., Augustijnsp, P., Kawakami, K., Yamashita, S.: Biopredictive in vitro testing methods to assess intestinal drug absorption from supersaturating dosage forms. J. Drug. Deliv. Sci. Technol., 56, 101275 (2020). https://doi.org/10.1016/j.jddst.2019.101275
Ueda, K., Okada, H., Zhao, Z., Higashi, K., Moribe, K.: Application of solid-state 13C relaxation time to prediction of the recrystallization inhibition strength of polymers on amorphous felodipine at low polymer loading.. Int. J. Pharm., 581, 119300 (2020). https://doi.org/10.1016/j.ijpharm.2020.119300
Tanaka, H., Takahashi, T., Konishi, M., Takata, N., Gomi, M., Shirane, D., Miyama, R., Hagiwara, S., Yamasaki, Y., Sakurai, Y., Ueda, K., Higashi, K., Moribe, K., Shinsho, E., Nishida, R., Fukuzawa, K., Yonemochi, E., Okuwaki, K., Mochizuki, Y., Nakai, Y., Tange, K., Yoshioka, H., Tamagawa, S., Akita, H.: Self‐degradable lipid‐like materials based on “hydrolysis accelerated by the intra‐particle enrichment of reactant (HyPER)” for messenger RNA delivery. Adv. Funct. Mater., 30, 1920575 (2020). https://doi.org/10.1002/adfm.201910575
Ueda, K., Hate, S. S., Taylor, L. S.: Impact of hypromellose acetate succinate grade on drug amorphous solubility and in vitro membrane transport. J. Pharm. Sci. , 190(8), 2464-2473 (2020). https://doi.org/10.1016/j.xphs.2020.04.014
Kosaka, M., Higashi, K., Nishimura, M., Ueda, K., Moribem K.: Clarification of the dissolution mechanism of an indomethacin/ saccharin/polyvinylpyrrolidone ternary solid dispersion by NMR spectroscopy. J. Pharm. Sci. , 109(12), 3617-3624 (2020). https://doi.org/10.1016/j.xphs.2020.09.009
Omagari, K., Ueda, K., Zhijing, Z., Higashi, K., Inoue, M., Fukami, T., Moribe, K.: Mechanistic study of preparation of drug/polymer/surfactant ternary hot extrudates to obtain small and stable drug nanocrystal suspensions. Int. J. Pharm., 591, 120003 (2020). https://doi.org/10.1016/j.ijpharm.2020.120003
2019
Ueda, K., Yamamoto, N., Higashi, K., Moribe, K.: Molecular mobility suppression of ibuprofen-rich amorphous nanodroplets by HPMC revealed by NMR relaxometry and its significance with respect to crystallization inhibition. Mol. Pharm., 16(12), 4968-4977 (2019). https://doi.org/10.1021/acs.molpharmaceut.9b00840
Higashi, K., Ueda, K., Moribe, K.: Intermolecular interactions between drugs and aminoalkyl methacrylate copolymer in solution to enhance the concentration of poorly water-soluble drugs. Chem. Pharm. Bull., 67 (9), 906-914 (2019). https://doi.org/10.1248/cpb.c18-00849
Iwashita, M., Hashizume, K., Umehara, M., Ishigami, T., Onishi, S., Yamamoto, M., Higashi, K., Moribe, K.: Development of nobiletin?methyl hesperidin amorphous solid dispersion: Novel application of methyl hesperidin as an excipient for hot-melt extrusion. Int. J. Pharm., 558(10), 215-224 (2019). https://doi.org/10.1016/j.ijpharm.2018.12.092
Shinozaki, T., Ono, M., Higashi, K., Moribe, K.: A novel drug-drug co-crystal of levofloxacin and metacetamol: Reduced hygroscopicity and improved photostability of levofloxacin. J. Pharm. Sci., 108 (7), 2383-2390 (2019). https://doi.org/10.1016/j.xphs.2019.02.014
Ueda, K., Higashi, K., Moribe, K.: Mechanistic elucidation of formation of drug-rich amorphous nanodroplets by dissolution of the solid dispersion formulation. Int. J. Pharm., 561(20), 82-92 (2019). https://doi.org/10.1016/j.ijpharm.2019.02.034
Zhao, Z., Katai, H., Higashi, K., Ueda, K.,Kawakami, K., Moribe, K.: Cryo-TEM and AFM observation of the time-dependent evolution of amorphous probucol nanoparticles formed by the aqueous dispersion of ternary solid dispersions. Mol. Pharm., 16(5), 2184-2198 (2019). https://doi.org/10.1021/acs.molpharmaceut.9b00158
Ueda, K., Iwai, T., Sunazuka, Y., Chen, Z., Kato, N., Higashi, K., Moribe, K.: Effect of molecular weight of hypromellose on mucin diffusion and oral absorption behavior of fenofibrate nanocrystal. Int. J. Pharm., 564(10), 39-47 (2019). https://doi.org/10.1016/j.ijpharm.2019.04.033
Ishizuka, Y., Ueda, K., Okada, H., Takeda, J., Karashima, M., Yazawa, K., Higashi, K., Kawakami, K., Ikeda, Y., Moribe, K.:Effect of drug-polymer interactions through hypromellose acetate succinate substituents on the physical stability on solid dispersions studied by Fourier-transform infrared and solid-state nuclear magnetic resonance. Mol. Pharm., 16(6), 2785-2794 (2019). https://doi.org/10.1021/acs.molpharmaceut.9b00301
2018
Kuroiwa, Y., Higashi, K., Ueda, K., Yamamoto, K., Moribe, K.: Nano-scale and molecular-level understanding of wet-milled indomethacin/poloxamer 407 nanosuspension with TEM, suspended-state NMR, and Raman measurements. Int. J. Pharm., 537 (1-2), 30-39 (2018). https://doi.org/10.1016/j.ijpharm.2017.12.028
Takahashi, N., Higashi, K., Ueda, K., Yamamoto, K., Moribe, K.: Determination of nonspherical morphology of doxorubicin-loaded liposomes by atomic force microscopy. J. Pharm. Sci., 107 (2), 717-726 (2018). https://doi.org/10.1016/j.xphs.2017.10.009
Ueda, K., Kanaya, H., Higashi, K., Yamamoto, K., Moribe, K.: Molecular-level elucidation of saccharin-assisted rapid dissolution and high supersaturation level of drug from Eudragit® E solid dispersion. Int. J. Pharm., 538(1-2), 57-64 (2018). https://doi.org/10.1016/j.ijpharm.2017.12.050
Morio, H., Sun, Y., Harada, M., Ide, H., Shimozato, O., Zhou, X. Higashi, K., Yuki, R., Yamaguchi, N., Hofbauer, J.P., Guttmann-Gruber, C., Anzai, N., Akita, H., Chiba, K., Furihata, T.: Cancer-type OATP1B3 mRNA in extracellular vesicles as a promising candidate for a serum-based colorectal cancer biomarker. Biol. Pharm. Bull., 41(3), 445-449 (2018). https://doi.org/10.1248/bpb.b17-00743
Yonashiro, H., Higashi, K., Morikawa, C., Ueda, K., Itoh, T., Ito, M., Masu, H., Noguchi, S., Moribe, K.: Morphological and physicochemical evaluation of two distinct glibenclamide/hypromellose amorphous nanoparticles prepared by the antisolvent method. Mol. Pharm., 15(4), 1587-1597 (2018). https://doi.org/10.1021/acs.molpharmaceut.7b01122
Sunazuka, Y., Ueda, K., Higashi, K., Tanaka, Y., Moribe, K.: Combined effects of the drug distribution and mucus diffusion properties of self-microemulsifying drug delivery systems on the oral absorption of fenofibrate. Int. J. Pharm., 546 (1), 263-271(2018). https://doi.org/10.1016/j.ijpharm.2018.05.031
Ueda, K., Yamazoe, C., Yasuda, Y., Higashi, K., Kawakami, K., Moribe, K.: Mechanism of enhanced nifedipine dissolution by polymer-blended solid dispersion through molecular-level characterization. Mol. Pharm., 15(9),4099-4109 (2018). https://doi.org/10.1021/acs.molpharmaceut.8b00523
Benjasirimongkol, P., Ueda, K., Higashi, K., Sriamornsak, P., Moribe, K.: An insight into stabilization mechanism of a solid dispersion of indomethacin/partially hydrolyzed polyvinyl alcohol prepared by hot-melt extrusion. Chem. Pharm. Bull.,66 (9), 859-865(2018). https://doi.org/10.1248/cpb.c18-00362
2017
K. Higashi, F. Mibu, K. Saito, W. Limwikrant, K. Yamamoto, K. Moribe. Composition-dependent structural changes and antitumor activity of ASC-DP/DSPE-PEG nanoparticles. Eur. J. Pharm. Sci., 99, 24-31 (2017). https://doi.org/10.1016/j.ejps.2016.11.029
N. Ohyagi, K. Ueda, K. Higashi, K. Yamamoto, K. Kawakami, K. Moribe. Synergetic role of hypromellose and methacrylic acid copolymer in the dissolution improvement of amorphous solid dispersions. J. Pharm. Sci., 106 (4), 1042-1050 (2017). https://doi.org/10.1016/j.xphs.2016.12.005
M. Ogawa, K. Higashi, S. Namiki, N. Liu, K. Ueda, W. Limwikrant, K. Yamamoto, K. Moribe. A solid-phase mediated methodology to incorporate drug into intermolecular spaces of CD columns in the PEG/CD-polypseudorotaxanes by cogrinding and subsequent heating. Cryst. Growth Des., 17 (3), 1055-1068 (2017). https://doi.org/10.1021/acs.cgd.6b01410
C. Aoki, Y. Takeuchi, K. Higashi, Y. Okamoto, A. Nakanishi, M. Tandia, J. Uzawa, K. Ueda, K. Moribe. Structural elucidation of a novel transglycosylated compound α-glucosyl rhoifolin and of α-glucosyl rutin by NMR spectroscopy. Carbohydr. Res., 443-444 (18), 37-41 (2017). https://doi.org/10.1016/j.carres.2017.03.011
R. Kinoshita, T. Ohta, K. Shiraki, K. Higashi, K. Moribe. Effects of wet-granulation process parameters on the dissolution and physical stability of a solid dispersion. Int. J. Pharm., 524 (1), 304-311 (2017). https://doi.org/10.1016/j.ijpharm.2017.04.007
M. Kitajima, A. Morita, S. Endo, N. Kogure, K. Higashi, K. Moribe, H. Takayama. Design and synthesis of 4-chlorocolchicine-derived prodrug capable of forming nanoparticles by self-assembly. Heterocycles, 95 (1), 181-186 (2017). https://doi.org/10.3987/COM-16-S(S)51
N. Liu, K. Higashi, K. Ueda, K. Moribe. Effect of guest drug character encapsulated in the cavity and intermolecular spaces of γ-cyclodextrins on the dissolution property of ternary γ-cyclodextrin complex. Int. J. Pharm., 531 (2), 543-549 (2017). https://doi.org/10.1016/j.ijpharm.2017.04.049
K. Ueda, K. Higashi, K. Moribe. Direct NMR monitoring of phase separation behavior of highly supersaturated nifedipine solution stabilized with hypromellose derivatives. Mol. Pharm., 14 (7), 2314–2322 (2017). https://doi.org/10.1021/acs.molpharmaceut.7b00178
S. Furukawa, Y. Hirakura, K. Moribe, Continuous screening of analytical parameters facilitates efficient development of HPLC methods required for impurity profiling. J. Liq. Chromatogr. Relat. Technol., 40 (11), 564-575 (2017). https://doi.org/10.1080/10826076.2017.1334214
K. Higashi, K. Ueda, K. Moribe. Recent progress of structural study of polymorphic pharmaceutical drugs. Adv. Drug Deliv. Rev., 117, 71-85 (2017). https://doi.org/10.1016/j.addr.2016.12.001
2016
K. Ueda, K. Higashi, K. Moribe. Application of solid-state NMR relaxometry for characterization and formulation optimization of grinding-induced drug nanoparticle. Mol. Pharm., 13 (3), 852-862 (2016). https://doi.org/10.1021/acs.molpharmaceut.5b00781
D. Ge, K. Higashi, D. Ito, K. Nagano, R. Ishikawa, Y. Terui, K. Higashi, K. Moribe, J.R. Linhardt, T. Toida. Poly-ion complex of chondroitin sulfate and spermine and its effect on oral chondroitin sulfate bioavailability. Chem. Pharm. Bull., 64(5), 390-398 (2016). https://doi.org/10.1248/cpb.c15-00940
N. Liu, K. Higashi, J. Kikuchi, S. Ando, N. Kameta, W. Ding, M. Masuda, T. Shimizu, K. Ueda, K. Yamamoto, K. Moribe K. Molecular-level understanding of the encapsulation and dissolution of poorly water-soluble ibuprofen by functionalized organic nanotubes using solid-state NMR spectroscopy. J. Phys. Chem. B, 120 (19), 4496-4507 (2016). https://doi.org/10.1021/acs.jpcb.6b00939
H. Sasako, F. Kihara, K. Koyama, K. Higashi, K. Yamamoto, K. Moribe. A novel capsule-like structure of micro-sized particles formed by phytosterol ester and γ-cyclodextrin in water. Food Chem., 210, 269-275 (2016). https://doi.org/10.1016/j.foodchem.2016.04.103
OD. Putra, T. Yoshida, D. Umeda, K. Higashi, H. Uekusa, E. Yonemochi. Crystal structure determination of dimenhydrinate after more than 60 years: Solving salt-cocrystal ambiguity via solid-state characterizations and solubility study. Cryst. Growth Des., 16 (9), 5223-5229 (2016). https://doi.org/10.1021/acs.cgd.6b00771
K. Higashi, A. Seo, K. Egami, N. Otsuka, W. Limwikrant, K. Yamamoto, K. Moribe. Mechanistic insight into the dramatic improvement of probucol dissolution in neutral solutions by solid dispersion in Eudragit® E PO with saccharin. J. Pharm. Pharmacol., 68(5), 655-664 (2016).https://doi.org/10.1111/jphp.12469
2015
T. Sato, H. Takeuchi,T. Sakurai, K. Tanaka, K. Matsuki, K. Higashi, K. Moribe,K. Yamamoto. Characterization of a riboflavin non-aqueous nanosuspension prepared by bead milling for cutaneous application. Chem. Pharm. Bull., 63 (2), 88-94 (2015). https://doi.org/10.1248/cpb.c14-00641
K. Ueda, K. Higashi, K. Yamamoto, K. Moribe. Equilibrium state at supersaturated drug concentration achieved by hydroxypropyl methylcellulose acetate succinate: molecular characterization using 1H NMR technique. Mol. Pharm., 12 (4), 1096-1104 (2015). https://doi.org/10.1021/mp500588x
Y. Hasegawa, K. Higashi, K. Yamamoto, K. Moribe. Direct evaluation of molecular states of piroxicam/poloxamer nanosuspension by suspended-state NMR and Raman spectroscopies. Mol. Pharm., 12 (5), 1564-1572 (2015). https://doi.org/10.1021/mp500872g
K. Abe, K. Higashi, K. Watabe, K. Kobayashi, W. Limwikrant, K. Yamamoto, K. Moribe. Effects of the PEG molecular weight of a PEG-lipid and cholesterol on PEG chain flexibility on liposome surfaces. Colloids Surf. A., 474 (5), 63-70 (2015). https://doi.org/10.1016/j.colsurfa.2015.03.006
K. Ueda, K. Higashi, K. Yamamoto, K. Moribe. In situ molecular elucidation of drug supersaturation achieved by nano-sizing and amorphization of poorly water-soluble drug. Eur. J. Pharm. Sci., 77, 79-89 (2015). https://doi.org/10.1016/j.ejps.2015.05.027
N. Otsuka, K. Ueda, N. Ohyagi, K. Shimizu, K. Katakawa, T. Kumamoto, K. Higashi, K. Yamamoto, K. Moribe. An insight into different stabilization mechanisms of phenytoin derivatives supersaturation by HPMC and PVP. J. Pharm. Sci., 104 (8), 2574-2582 (2015). https://doi.org/10.1002/jps.24527
K. Egami, K. Higashi, K. Yamamoto, K. Moribe. Crystallization of probucol in nanoparticles revealed by AFM analysis in aqueous solution. Mol. Pharm., 12 (8), 2972-2980 (2015). https://doi.org/10.1021/acs.molpharmaceut.5b00236
K. Higashi, H. Hayashi K. Yamamoto, K. Moribe. The effect of drug and Eudragit® S 100 miscibility in solid dispersions on the drug and polymer dissolution rate. Int. J. Pharm., 494 (1), 9-16 (2015). https://doi.org/10.1016/j.ijpharm.2015.08.007
K. Nagai, T. Ushio, H. Miura, K. Moribe, K.Yamamoto, Effect of enantiotropic uniformity of polymorphic crystals on the chemical stability of suplatast tosilate. J. Drug Deliv. Sci. Technol., 27, 37-45 (2015). https://doi.org/10.1016/j.jddst.2015.04.004
S. Sasaoka, K. Saito, K. Higashi, W. Limwikrant, K. Moribe, S. Suzuki, K. Yamamoto. Design of one-dimensional power spectrum using two-dimensional fast Fourier transform for discrimination of paper-based kraft tapes.Forensic Sci. Int., 257, 329-336 (2015). https://doi.org/10.1016/j.forsciint.2015.09.016
2014
M. Osawa, K. Higashi, J. Yamashita, K. Moribe, K. Yamamoto. Characterization of sulindac solid dispersion with hydroxypropyl cellulose prepared by hot melt extrusion. J. Pharm. Sci. Technol. Jpn., 74 (2), 160-169 (2014). https://doi.org/10.14843/jpstj.74.160
K. Ueda, K. Higashi, K. Yamamoto, K. Moribe. The effect of HPMCAS functional groups on drug crystallization from the supersaturated state and dissolution improvement. Int. J. Pharm., 464 (1), 205-213 (2014). https://doi.org/10.1016/j.ijpharm.2014.01.005
J. Zhang, K. Higashi, K. Ueda, K. Kadota, Y. Tozuka, W. Limwikrant, K. Yamamoto, K. Moribe. Drug solubilization mechanism of α-glucosyl stevia by NMR spectroscopy. Int. J. Pharm., 465 (1), 255-261 (2014). https://doi.org/10.1016/j.ijpharm.2014.01.035
K. Higashi, H. Waraya, L. K. Lin, S. Namiki, M. Ogawa, W. Limwikrant, K. Yamamoto, K. Moribe. Application of intermolecular spaces between polyethylene glycol/γ-cyclodextrin-polypseudorotaxanes as a host for various guest drugs. Cryst. Growth Des., 14 (6), 2773-2781 (2014). https://doi.org/10.1021/cg401934v
K. Moribe, T. Makishima, K. Higashi, N. Liu, W. Limwikrant, W. Ding, M. Masuda, T. Shimizu, K. Yamamoto. Encapsulation of poorly water-soluble drugs into organic nanotubes for improving drug dissolution. Int. J. Pharm., 469 (1), 190-196 (2014). https://doi.org/10.1016/j.ijpharm.2014.04.005
R. Koike, K. Higashi, N. Liu, W. Limwikrant, K. Yamamoto, K. Moribe. Structural determination of a novel polymorph of sulfathiazole-oxalic acid complex in powder form by solid-state NMR spectroscopy on the basis of crystallographic structure of another polymorph. Cryst. Growth Des., 14 (9), 4510-4518 (2014). https://doi.org/10.1021/cg5005903
K. Ueda, K. Higashi, M. Kataoka, S. Yamashita, K. Yamamoto, K. Moribe. Inhibition mechanism of hydroxypropyl methylcellulose acetate succinate on drug crystallization in gastrointestinal fluid and drug permeability from a supersaturated solution. Eur. J. Pharm. Sci., 62, 293-300 (2014). https://doi.org/10.1016/j.ejps.2014.06.007
R. Chiba, Y. Kuroiwa, K. Higashi, K. Yamamoto, K. Moribe. Characterization of as-synthesized mesoporous silica using NMR and solid-state fluorescence spectroscopy. J. Drug Deliv. Sci. Technol., 24 (6), 673-677 (2014). https://doi.org/10.1016/S1773-2247(14)50135-9
T. Nakahashi, T. Matsumoto, N. Wakiyama, K. Moribe, K. Yamamoto. The role of light anhydrous silicic acid on physical stability of troglitazone solid dispersion under humidified conditions. Adv. Powder Tech., 25 (2), 716-721 (2014). https://doi.org/10.1016/j.apt.2013.10.020
K. Ajito, Jae-Young Kima, Y. Ueno, Ho-Jin Songa, K. Ueda, W. Limwikrant, K. Yamamoto, K. Moribe. Nondestructive multicomponent terahertz chemical imaging of medicine in tablets. J. Electrochem. Soc., 161 (9), B171-B175 (2014). http://doi.org/10.1149/2.0201409jes
K. Higashi, K. Yamamoto, M. K. Pandey, K. H. Mroue, K. Moribe, K. Yamamoto, A. Ramamoorthy. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR Spectroscopy. Mol. Pharm., 11 (1), 351-357 (2014). https://doi.org/10.1021/mp4005723
K. Nagai, T. Ushio, H. Miura, T. Nakamura, K. Moribe, K. Yamamoto. Four new polymorphic forms of suplatast tosilate. Int. J. Pharm., 460 (1-2), 83-91 (2014) https://doi.org/10.1016/j.ijpharm.2013.10.049
2013
M. Fushimi, K. Moribe, K. Higashi, K. Yamamoto. Intermolecular interaction between low-substituted hydroxypropylcellulose and water-soluble drugs in granules prepared by wet granulation. J. Pharm. Sci. Technol. Jpn. , 73(1), 72-81 (2013). https://doi.org/10.14843/jpstj.73.72
M. Umino, K. Higashi, H. Masu, W. Limwikrant, K. Yamamoto, K. Moribe. Characterization of cromolyn sodium hydrates and its formulation by 23Na-multiquantum and magic-angle spinning nuclear magnetic resonance spectroscopy. J. Pharm. Sci., 102(8), 2738-2747 (2013). https://doi.org/10.1002/jps.23655
K. Ueda, K. Higashi, K. Yamamoto, K. Moribe. Inhibitory effect of hydroxypropyl methylcellulose acetate succinate on drug recrystallization from a supersaturated solution assessed using nuclear magnetic resonance measurements. Mol. Pharm., 10(10), 3801-3811 (2013). https://doi.org/10.1021/mp400278j
K. Moribe, K. Ueda, W. Limwikrant, K. Higashi, K. Yamamoto,. Nano-sized crystalline drug production by milling technology. Curr. Pharm. Des., 19(35), 6246-6258 (2013). https://doi.org/10.2174/1381612811319350003
F. Uejo, W. Limwikrant, K. Moribe, K. Yamamoto. Dissolution improvement of fenofibrate by melting inclusion in mesoporous silica. Asian J. Pharm. Sci., 8(6), 329-335 (2013). https://doi.org/10.1016/j.ajps.2013.11.001
2012
N. Miyadai, K. Higashi, K. Moribe, K.Yamamoto: Optimization and characterization of direct coating for ibuprofen particles using a composite fluidized bed. Adv. Powder Tech., 23, 40-45 (2012).
I.O. Umeda, K. Tani, K. Tsuda, M. Kobayashi, M. Ogata, S. Kimura, M. Yoshimoto, S. Kojima, K. Moribe, K. Yamamoto, N. Moriyama, H. Fujii, High resolution SPECT imaging for visualization of intratumoral heterogeneity using a SPECT/CT scanner dedicated for small animal imaging. Ann. Nucl. Med., 26,67-76 (2012).
J. Zhang, K. Higashi, W. Limwikrant, K. Moribe, K. Yamamoto, Molecular-level characterization of probucol nanocrystal in water by in situ solid-state NMR spectroscopy. Int. J. Pharm., 423, 571-576 (2012).
森部久仁一, 永井愛子, 萩原由実, W. Limwikrant, 東顕二郎, 山本恵司: 多成分混合粉砕によるカルバマゼピン-ジカルボン酸共結晶形成:ジカルボン酸の交換反応. 粉体工学会誌,, 49, 184-190 (2012).
Y. Ikeda, K. Higashi, K. Moribe, K. Yamamoto, Enhanced skin permeation of piroxicam and pranoprofen induced from nanoparticles dispersed in propylene glycol aqueous solution. J. Drug Del. Sci. Tech., 22, 131-137 (2012).
W. Limwikrant, M. Osada, K. Higashi, Y. Tozuka, K. Moribe, K. Yamamoto, Unique indomethacin nanoparticles formation by cogrinding with dextrin under defined moisture conditions. Powder Tech., 221, 213-219 (2012).
K. Moribe, W. Limwikrant, K. Higashi, K. Yamamoto, Structural evaluation of probucol nanoparticles in water by atomic force microscopy. Int. J. Pharm., 427, 365-371 (2012).
S. Tanabe, K. Higashi, M. Umino, W. Limwikrant, K. Yamamoto, K. Moribe. Yellow coloration phenomena of incorporated indomethacin into folded sheet mesoporous materials. Int. J. Pharm., 429, 38-45 (2012).
S. Sasaoka, K. Saito, K. Higashi, W. Limwikrant, K. Moribe, S. Suzuki, K. Yamamoto, Discrimination of paper-based kraft tapes using Fourier transform of transmitted light images. Forensic Sci. Int., 220, 59-66 (2012).
W. Limwikrant, A. Nagai, Y. Hagiwara, K. Higashi, K. Yamamoto, K. Moribe. Formation mechanism of a new carbamazepine/malonic acid cocrystal polymorph. Int. J. Pharm., 431, 237-240 (2012).
S. Ando, J. Kikuchi, Y. Fujimura, Y. Ida, K. Higashi, K. Moribe, K. Yamamoto. Physicochemical characterization and structural evaluation of a specific 2:1 cocrystal of naproxen-nicotinamide. J. Pharm. Sci., 101, 3214-3221 (2012).
K. Moribe, A. Ogino, T. Kumamoto, T. Ishikawa, W. Limwikrant, K. Higashi, K. Yamamoto. Mechanism of nanoparticle formation from ternary coground phenytoin and its derivatives. J. Pharm. Sci., 101, 3413-3424 (2012).
T. Kojima, K. Higashi, T. Suzuki, K. Tomono, K. Moribe, K. Yamamoto, Stabilization of a Supersaturated Solution of Mefenamic Acid from a Solid Dispersion with EUDRAGIT® EPO. Pharm. Res., 29, 2777-2791 (2012).
Y. Tozuka, K. Higashi, T. Morita, M. Nishikawa, H. Uchiyama, J. Zhang, K. Moribe, K. Nishikawa, H. Takeuchi, K. Yamamoto. Transglycosylated rutin-specific non-surface-active nanostructure affects absorption enhancement of flurbiprofen. Eur J Pharm Biopharm., 82, 120-126 (2012).
K. Ueda, K. Higashi, W. Limwikrant, S. Sekine, T. Horie, K. Yamamoto, K..Moribe. Mechanistic differences in permeation behavior of supersaturated and solubilized solutions of carbamazepine revealed by nuclear magnetic resonance measurements. Mol. Pharm., 9, 3023-3033 (2012).
G. Yan, K. Moribe, M. Otsuka, K. Papangkorn, W.I. Higuchi. Quantitative determination of lattice fluoride effects on the solubility and crystallinity of carbonated apatites with incorporated fluoride. Caries Res., 47, 193-202 (2012).
K. Ajito, Y. Ueno, H.-J. Song, J.-Y. Kim, E. Tamechika, N. Kukutsu, W. Limwikrant, K. Yamamoto, K. Moribe. Terahertz chemical imaging of a multicomponent tablet in pharmaceutical applications. ECS Transactions, 50, 109-116 (2012).
2010-2011
Ito, A., Watanabe, T., Yada, S., Hamaura, T., Nakagami, H., Higashi, K., Moribe, K., Yamamoto, K.: Prediction of recrystallization behavior of troglitazone/ polyvinylpyrrolidone solid dispersion by solid-state NMR. Int. J. Pharm., 383, 18-23 (2010).
Hanawa, K., Hanawa, T., Tsuchiya, C., Higashi, K., Suzuki, M., Moribe, K., Yamamoto, K., Oguchi, T.: Development of sarpogrelate external preparation for intractable pain control. I. Pre-formulation study on application of modified beta-cyclodextrins. Chem. Pharm. Bull., 58, 45-50 (2010).
Moribe, K., Kinoshita, R., Higashi, K., Tozuka, Y., Yamamoto, K.: Coloration phenomenon of mefenamic acid in mesoporous silica FSM-16. Chem. Pharm. Bull., 58, 214-218 (2010).
Moribe, K., Maruyama, S., Inoue, Y., Suzuki, T., Fukami, T., Tomono, K., Higashi, K., Tozuka, Y., Yamamoto, K.: Ascorbyl dipalmitate/PEG-lipid nanoparticles as a novel carrier for hydrophobic drugs. Int. J. Pharm., 387, 236-243 (2010).
Hasui, A., Moribe, K., Yamamoto, K.: Transdermal iontophoretic delivery of [3H]-betamethasone sodium phosphate to the hind knee joints of rabbits: Visualization of drug permeation routes and distributions. J. Drug Del. Sci. Tech., 20, 101-105 (2010).
Higashi, K., Ideura, S., Waraya, H., Limwikrant, W., Moribe, K., Yamamoto, K.: Simultaneous dissolution of naproxen and flurbiprofen from a novel ternary gamma-cyclodextrin complex. Chem. Pharm. Bull., 58, 769-772 (2010).
Moribe, K., Shibata, M., Furuishi, T., Higashi, K., Tomono, K., Yamamoto, K.: Effect of particle size on skin permeation and retention of piroxicam in aqueous suspension. Chem. Pharm. Bull., 58, 1096-1099 (2010).
Higashi, K., Tozuka, Y., Moribe, K., Yamamoto, K.: Salicylic acid/γ-cyclodextrin 2:1 and 4:1 complex formation by sealed-heating method. J. Pharm. Sci., 99, 4192-4200 (2010).
Ogawa, N., Higashi, K., Nagase, H., Endo, T., Moribe, K., Loftsson, T., Yamamoto, K., Ueda, H.: Effects of cogrinding with β-cyclodextrin on the solid state fentanyl. J. Pharm. Sci., 99, 5019-5029 (2010).
Higashi, K., Ideura, S., Waraya, H., Moribe, K., Yamamoto, K.: Structural evaluation of crystalline ternary γ-cyclodextrin complex. J. Pharm. Sci., 100, 325-333 (2011).
Yamamoto, K., Limwikrant, W., Moribe, K.: Analysis of molecular interactions in solid dosage forms; challenge to molecular pharmaceutics. Chem. Pharm. Bull., 59, 147-154 (2011).
Moribe, K., Limwikrant, W., Higashi, K., Yamamoto, K.: Drug nanoparticle formulation using ascorbic Acid derivatives. J. Drug Deliv., 2011, 2011:138929.
Inoue, Y., Hasegawa, N., Tozuka, Y., Yonemochi, E., Oguchi, T., Higashi, K., Moribe, K., Yamamoto, K.: Molecular states of p-dimethylaminobenzonitrile coground with β-cyclodextrin investigated using solid-state fluorescence spectroscopy. Chem. Pharm. Bull., 59, 1299-302 (2011).
Moribe, K., Masaki, M., Kinoshita, R., Zhang, J., Limwikrant, W., Higashi, K., Tozuka, Y., Oguchi, T., Yamamoto, K.: Guest molecular size-dependent inclusion complexation of parabens with cholic acid by cogrinding. Int. J. Pharm., 420, 191-197 (2011).
Tsutsumi, S., Iida, M., Tada, N., Kojima, T., Ikeda, Y., Moriwaki, T., Higashi, K., Moribe, K., Yamamoto, K.: Characterization and evaluation of miconazole salts and cocrystals for improved physicochemical properties. Int. J. Pharm., 421, 230-236 (2011).
Zhang, J., Tozuka, Y., Uchiyama, H., Higashi, K., Moribe, K., Takeuchi, H., Yamamoto, K.: NMR investigation of a novel excipient, α-glucosylhesperidin, as a suitable solubilizing agent for poorly water-soluble drugs. J. Pharm. Sci., 100, 4421-4431 (2011).
Iohara, D., Hirayama, F., Higashi, K., Yamamoto, K., Uekama. K.: Formation of stable hydrophilic C60 nanoparticles by 2-hydroxypropyl-β-cyclodextrin. Mol. Pharm., 8, 1276-1284 (2011).
2008-2009
Chingunpitak J., Puttipipatkhachorn S., Petmitr P., Tozuka Y., Moribe K., Yamamoto K.: Physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by co-grinding method. Drug Dev. Ind. Pharm., 34, 314-322 (2008).
K. Moribe Y. Tozuka, K. Yamamoto: Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation, Adv. Drug Delivery Rev., 60, 328-338 (2008).
K. Papangkorn, G. Yan, D. D. Heslop, K. Moribe, A. A. Baig, M. Otsuka, W. I. Higuchi: Influence of crystallite microstrain on surface complexes governing the metastable equilibrium solubility behavior of carbonated apatites. J. Colloid Int. Sci., 320, 96-109 (2008).
A. Pongpeerapat, C. Wanawongthai, Tozuka, K. Moribe, K. Yamamoto: Formation mechanism of colloidal nanoparticles obtained from probucol/PVP/SDS ternary ground mixture. Int. J. Pharm., 352, 309-316 (2008).
J. Shudo, A. Pongpeerapat, C. Wanawongthai, K. Moribe, K. Yamamoto: In vivo assessment of oral administration of probucol nanoparticles in rats. Biol. Pharm. Bull., 31, 321-325 (2008).
大野育正, 長谷川晋, 伊藤敦俊, 矢田修一, 濱浦健司, 草井章, 中上博秋, 森部久仁一, 山本恵司: 医薬品の溶出特性に影響する造粒工程の製造パラメーターに関する製剤学的研究. 製剤機械技術研究会誌, 17, 5-16 (2008).
A. Kajiyama, H. Takagi, K, Moribe, K. Yamamoto: Improvement of HPMC tablet disintegration by the addition of inorganic salts. Chem. Pharm. Bull., 56, 598-601 (2008).
K. Moribe, C. Wanawongthai, J. Shudo, K. Higashi, K.Yamamoto: Morphology and surface states of colloidal probucol nanoparticles evaluated by atomic force microscopy. Chem. Pharm. Bull., 56, 878-880 (2008).
J. Chingunpitak, S. Puttipipatkhachorn, Y. Tozuka, K. Moribe, K. Yamamoto: Micronization of dihydroartemisinin by rapid expansion of supercritical solutions. Drug Dev. Ind. Pharm., 34, 609-617 (2008).
井上裕、 神谷亨子、 尾高亜矢子、 則武和子、 金本郁男、 東顕二郎、 森部久仁一、山本恵司: 地域小規模病院における糖尿病及び高血圧患者への一般名処方の現状. Progress in medicine, 28, 2013-2019 (2008).
K. Moribe, N. Nomizu, S. Izukura, K. Yamamoto, Y. Tozuka, M. Sakurai, A. Ishida, H. Nishida, M. Miyazaki: Physicochemical, morphological and therapeutic evaluation of agarose hydrogel particles as a reservoir for basic fibroblast growth factor. Pharm. Dev. Technol. 13, 541-547(2008).
深水啓朗, 戸塚裕一, 森部久仁一, 鈴木豊史, 伴野和夫,小口敏夫, 山本恵司: メカノケミカル反応による共結晶の形成-極低温において混合粉砕したウルソデオキシコール酸及びフェナントレンの物性評価. 製剤機械技術研究会誌, 17, 326-333 (2008).
T. Tomizawa, A. Watanabe, W. Limwikrant, Y. Tozuka, K. Moribe, K. Yamamoto, Takamatsu S., Nakajima S.: Molecular incorporation of benzoic acid and salicylic acid into BEA zeolites. Asian J. Pharm. Sci., 3, 233-239 (2008).
井上裕, 井紀孝, 米持悦生, 小口敏夫, 東顕二郎, 森部久仁一, 山本恵司: 固体蛍光測定によるシクロデキストリン混合粉砕物中のp-ジメチルアミノベンゾニトリルの分子状態. YAKUGAKU ZASSHI, 129, 253-262 (2009).
T. Yamamura, T. Ohta, T. Taira, Y. Ogawa, Y. Sakai, K. Moribe, K. Yamamoto: Effects of automated external lubrication on tablet properties and the stability of eprazinone hydrochloride. Int. J. Pharm., 370, 1-7 (2009).
C. Wanawongthai, A. Pongpeerapat, K. Higashi, Y. Tozuka, K. Moribe, K. Yamamoto: Nanoparticle formation from probucol/PVP/sodium alkyl sulfate co-ground mixture. Int. J. Pharm., 376, 169-75 (2009).
A. Nishiwaki, A. Watanabe, K. Higashi, Y. Tozuka, K. Moribe, K. Yamamoto: Molecular states of prednisolone dispersed in folded sheet mesoporous silica; FSM-16. Int J Pharm. 378, 17-22 (2009).
K. Moribe, M. Fukino, Y. Tozuka, K. Higashi, K. Yamamoto: Prednisolone multicomponent nanoparticle preparation by aerosol solvent extraction system. Int. J. Pharm. 380, 201-205 (2009).
W. Limwikrant, K. Higashi, K. Yamamoto, K. Moribe: Characterization of ofloxacin-oxalic acid complex by PXRD, NMR, and THz spectroscopy. Int. J. Pharm. 382, 50-55 (2009).
Y. Tozuka, C. Yokohama, K. Higashi, K. Moribe, K. Yamamoto: Adsorption state of naphthoic acids on folded sheets mesoporous materials with different pore sizes. J. Drug Del. Sci. Tech. 19, 401-404 (2009).
Y. Onuki, K. Higashi, K. Moribe, K. Yamamoto: Improved chemical stability of ascorbic acid and thiamine nitrate in L-HPC granules. Adv. Powder Tech. 20, 576-581 (2009).
K. Higashi, S. Ideura, H. Waraya, K. Moribe, K. Yamamoto: Incorporation of salicylic acid molecules into the intermolecular spaces of γ-cyclodextrin-polypseudorotaxane. Cryst. Growth Des. 9, 4243-4246 (2009).
2006-2007
Saito H., Inoue K., Suzuki Y., Okada J., Nishimura K., Kurihara K., Asai F., Moribe K., Yamamoto K.: Feasibility of a prostacyclin analogue-containing silicone to anti-thrombosis material. Asian J. Pharm. Sci., 2, 85-95 (2007)
Ohno I., Hasegawa S., Yada S., Kusai A., Moribe K., Yamamoto K.: Importance of evaluating the consolidation of granules manufactured by high shear mixer. Int. J. Pharm., 338, 79-86 (2007)
Moribe K., Sekiya N., Fujito T., Yamamoto M., Higashi K., Yokohama C., Tozuka Y.,Yamamoto K.: Stabilization mechanism of limaprost in solid dosage form. Int. J. Pharm., 338, 1-6 (2007)
Moribe K., Fujito T., Tozuka Y., Yamamoto K.: Solubility-dependent complexation of active pharmaceutical ingredients with trimethyl- Symbol'>b-cyclodextrin under supercritical fluid condition. J. Incl. Phenom. Macrocycl. Chem., 57, 289-295 (2007)
Wongmekiat A., Tozuka Y., Moribe K., Oguchi T., Yamamoto K.: Preparation of drug nanoparticles by co-grinding with cyclodextrin: formation mechanism and factors affecting nanoparticle formation. Chem. Pharm. Bull., 55, 359-363 (2007)
Inoue Y., Yoshimura S., Tozuka Y., Moribe K., Kumamoto T., Ishikawa T.,Yamamoto K.: Application of ascorbic acid 2-glucoside as a solubilizing agent for clarithromycin: Solubilization and nanoparticle formation. Int. J. Pharm., 331, 38-45 (2007)
Pongpeerapat A., Higashi K., Tozuka Y., Moribe K., Yamamoto K.: Molecular interaction among probucol/PVP/SDS multicomponent system investigated by solid-state NMR. Pharm. Res., 23, 2566-2574 (2006)
Moribe K., Higashi K., Tozuka Y., Yamamoto.:Evaluation of Molecular States of Salicylic acid in 71- and 81-Amylose Complexes.J.Soc. Powder Technol Jpn., 43,633-639(2006
H. Shinozaki, T. Oguchi, S. Suzuki, K. Aoki, T. Sato, S. Morishita, Y. Tozuka, K. Moribe, K. Yamamoto: Micronization and polymorphic conversion of tolbutamide and barbital by rapid expansion of supercritical solutions, Drug. Dev. Ind. Pharm., 32, 877-891 (2006)
Y. Tozuka, A. Takeshita, A. Nagae, A. Wongmekiat, K. Moribe, T. Oguchi, K. Yamamoto: Specific inclusion mode of guest compounds in the amylose complex analyzed by solid state NMR spectroscopy, Chem. Pharm. Bull., 54, 1097-1101 (2006)
Y. Tozuka, T. Fujito, K. Moribe, K. Yamamoto: Ibuprofen-cyclodextrin inclusion complex formation using supercritical carbon dioxide, J. Incl. Phenom. Macro, 56, 29-32 (2006)
A. Wongmekiat, S. Yoshimatsu, Y. Tozuka, K. Moribe. K. Yamamoto: Investigation of Drug Nanoparticle Formation by Co-grinding with Cyclodextrins: Studies for Indomethacin, Furosemide and Naproxen, J. Incl. Phenom. Macrocyc. Chem., 56, 29-32 (2006)
K. Moribe, M. Tsuchiya, Y. Tozuka, K. Yamaguchi, T. Oguchi, and K. Yamamoto: Equimolar Complex Formation of Urea or Thiourea with 2-Alkoxy-benzamides: Structural Factors Required for the Equimolar Complex Formation, J. Incl. Phenom. Macrocyclic Chem., 54, 9-16 (2006)
K. Moribe, A. Pongpeerapat,Y. Tozuka, and K. Yamamoto., Drug Nanoparticle Formation from Drug/HPMC/SDS Ternary Ground Mixtures, Pharmazie, 61,97-101 (2006)
2004-2005
Y. Tozuka, S. Sasaoka, A. Nagae, K. Moribe, T. Oguchi, and K. Yamamoto, Rapid Adsorption and Entrapment of Benzoic Acid Molecules into the Mesoporous Silica (FSM-16), J. Colloid Interface Sci., 291, 471-476 (2005)
K. Moribe, S. Tsutsumi, S. Morishita, H. Shinozaki, Y. Tozuka, T. Oguchi, K. Yamamoto: Micronization of Phenylbutazone by Rapid Expansion of Supercritical CO2 Solution, Chem. Pharm. Bull., 53, 1025-1028 (2005)
Y. Tozuka, A. Wongmekiat, K. Kimura, K. Moribe, S. Yamamura, and K. Yamamoto: Effect of Pore Size of FSM-16 on the Entrapment of Flurbiprofen in Mesoporous Structures, Chem. Pharm. Bull., 53, 974-977 (2005)
M. Ono, H. Anzai, Y. Tozuka, K. Moribe, T. Oguchi, and K. Yamamoto: Water Vapor Adsorption Behavior of Sodium Deoxycholate Anhydrous Forms, Chem. Pharm. Bull., 53, 180-183 (2005)
K. Moribe, A. Wongmekiat, Y. Hyakutake, Y. Tozuka, T. Oguchi, and K. Yamamoto: Influence of Dehydration Temperature on Water Vapor Adsorption, Dissolution Behavior and Surface Property of Ampicillin, Int. J. Pharm., 288, 245-252 (2005)
W. S. Choi, H. I. Kin, S. S. Kwak, H. Y. Chung, H. Y. Chung, K. Yamamoto, T. Oguchi, Y. Tozuka, E. Yonemochi, and K. Terada: Amorphous Ultrafine Particle Preparation for Improvement of Bioavailability of Insoluble Drugs: Grinding Characteristics of Fine Grinding Mills, Int. J. Miner. Process., 74S, S165-S172 (2004)
Y. Tozuka, A. Wongmekiat, K. Sakata, K. Moribe, T. Oguchi, and K. Yamamoto: Co-grinding with Cyclodextrin as a Nanoparticle Preparation Method of a Poorly Water Soluble Drug, J. Incl. Phenom. Macrocyclic Chem., 50, 67-71 (2004
A. Pongpeerapat, K. Itoh, Y. Tozuka, K. Moribe T. Oguchi, and K. Yamamoto: Formation and Stability of Drug Nanoparticles Obtained from Drug/PVP/SDS Ternary Ground Mixture, J. Drug. Del. Sci. Tech., 14, 441-447 (2004)
S. Limmatvapirat, C. Limmatvapirat, M. Luangtana-anan, J. Nunthanid, T. Oguchi, Y. Tozuka, K. Yamamoto, and S. Puttipipatkhachorn: Modification of Physicochemical and Mechanical Properties of Shellac by Partial Hydrolysis, Int. J. Pharm., 278, 41-49 (2004)
K. Moribe, M. Tsuchiya, Y. Tozuka, K. Yamaguchi, T. Oguchi, and K. Yamamoto: Grinding-induced Equimolar Complex Formation between Thiourea and Ethenzamide, Chem. Pharm. Bull., 52, 524-529 (2004)
K. Moribe, R. Mochizuki, Y. Tozuka, T. Uchino, Y. Fukami, T. Oguchi, K. Yamamoto: Preparation of an Urea-Stearic Acid Inclusion Compound by Co-grinding Method, J. Jpn. Soc. Pharm. Mach. & Eng., 13, 5-10 (2004)
N. Aoyagi, H. Morikawa, T. Sonobe, K. Yamamoto, S. Kojima, Y. Hiyama, N. Kaniwa, N. Muranishi, Y. Sakai: Guidelines (Draft) for Bioequivalence Studies for Manufacturing Changes of Oral Solid Dosage Forms: Conventional and Enteric-coated Products, Iyakuhin Kenkyu, 35, 295-317 (2004)
2002-2003
K. Moribe, P. Sujimon, Y. Tozuka, E. Yonemochi, T. Oguchi, K. Yamamoto: Structural change and moisture sorption behavior of dl-valine induced by grinding, STP Pharma Sci., 13, 381-386 (2003)
A. Wongmekiat, Y. Tozuka, T. Oguchi, K. Yamamoto: Formation of fine drug particle by cogrinding with cyclodextrins: Part II: The Influence of moisture condition during cogrinding process on fine particle formation, Int. J. Pharm., 265, 85-93 (2003)
Y. Tozuka, D. Kawada, T. Oguchi, K. Yamamoto, Supercritical carbon dioxide treatment as a method for polymorph preparation of deoxycholic acid, Int. J. Pharm., 263, 45-50 (2003)
T. Oguchi, K. Kazama, T. Fukami, E. Yonemochi, and K. Yamamoto, Specific Complexation of Ursodeoxycholic Acid with Guest Compounds Induced by Co-grinding. II. Effect of Grinding Temperature on the Mechanochemical Complexation, Bull. Chem. Soc. Jpn., 76, 515-521 (2003)
S. Yada, M. Ohya, Y. Ohuchi, T. Hamaura, N. Wakiyama, F. Usui, A. Kusai, and K. Yamamoto, Solid phase transition of CS-891 enantiotropes during grinding, Int. J. Pharm., 255, 69-79 (2003)
H. Y. Chung, E. Yonemochi, T. Saitoh, K. Terada, Y. Tozuka, T. Oguchi, K. Yamamoto, H. Y-. Chung, and W. S. Choi, Factors affecting the apparent solubility of ursodeoxycholic acid in the grinding process, Int. J. Pharm., 255, 49-56 (2003)
K. Itoh, A. Pongpeerapat, Y. Tozuka, T. Oguchi, and K. Yamamoto, Nanoparticle Formation of Poorly Water-soluble Drugs from Ternary Ground Mixtures with PVP and SDS, Chem.Pharm. Bull., 52, 171-174 (2003)
T. Fukami, K. Yamaguchi, Y. Tozuka, K. Moribe, T. Oguchi, and K. Yamamoto, Novel Channel Structures of Bile Acid-Guest Inclusion Complex Formed between Ursodesoxycholic Acid and Phenanthlene, Chem. Pharm. Bull., 51, 227-229 (2003)
T. Oguchi, N. Sasaki, T. Hara, Y. Tozuka, and K. Yamamoto, Differentiated Thermal Crystallization from Amorphous Chenodeoxycholic Acid between the Ground Speciments Derived from the Polymorphs, Int. J. Pharm., 253, 81-88 (2003)
Y. Tozuka, T. Oguchi, and K. Yamamoto, Adsorption and Entrapment of Salicylamide Molecules into the Mesoporous Structure of Folded Sheets Mesoporous Material (FSM-16), Pharm. Res., 20, 926-931 (2003)
K. Itoh, Y. Tozuka, T. Oguchi, and K. Yamamoto, Improvement of Physicochemical Properties of N-4472. Part III. VC/N-4472 Complex Formation and Self-association in Aqueous Solution, Chem.Pharm. Bull., 51, 40-45 (2003)
A. Wongmekiat, Y. Tozuka, T. Oguchi, and K. Yamamoto, Formation of Drug Fine Particle by Cogrinding with Cyclodextrins. Part I: The Use of β-Cyclodextrin Anhydrate and Hydrate, Pharm. Res., 19, 1869-1874 (2002)
T. Uchino, Y. Tozuka, T. Oguchi, and K. Yamamoto, Inclusion Compound Formation of Amylose by Sealed-Heating with Salicylic Acid Analogues, J. Incl. Phenom., 43, 31-36 (2002)
K. Itoh, S. Matsui, Y. Tozuka, T. Oguchi and K. Yamamoto, Improvement of Physicochemical Properties of N-4472 Part II. Characterization of N-4472 Microemulsion and the Enhanced Oral Absorption, Int. J. Pharm., 246, 75-83 (2002)
H. Ishii, K.Yamaguchi, H. Seki, S. Sakamoto, Y. Tozuka, T. Oguchi, and K. Yamamoto, Crystal Structure of the Alcholates and the Ansolvate of PNU-97018, an Angiotensin II Recepter Antagonist, Chem.Pharm. Bull., 50, 1022-1027 (2002)
Y. Tozuka, A. Ito, H. Seki, T. Oguchi, and K. Yamamoto, Characterization and Quantitation of Clarithromycin Polymorphs by Powder X-ray Diffractometry and Solid-State NMR Spectroscopy, Chem. Pharm. Bull., 50, 1128-1130 (2002)
T. Oguchi, Y. Tozuka, T. Hanawa, M. Mizutani, N. Sasaki, S. Limmatvapirat, and K. Yamamoto, Elucidation of Solid-State Complexation in Ground Mixtures of Cholic Acid and Guest Compounds, Chem. Pharm. Bull., 50, 887-891 (2002)
M. Ono, Y. Tozuka, T. Oguchi, S. Yamamura, and K. Yamamoto, Effects of Dehydration Temperature on Water Vapor Adsorption and Dissolution Behavior of Carbamazepine, Int. J. Pharm., 239, 1-12 (2002)
T. Uchino, Y. Tozuka, W. S. Choi, T. Oguchi, and K. Yamamoto, Inclusion Behavior of Benzoic Acid Analogues to Linear Amylose by the Sealed-Heating Method, J. Pharm. Sci. Technol., Jpn., 62, 58-66 (2002)
K. Itoh, Y. Tozuka, T. Oguchi, and K. Yamamoto, Improvement of Physicochemical Properties of N-4472 Part I Formulation Design by Using Self-Microemulsifying System, Int. J. Pharm., 238, 153-160 (2002)
Y. Tozuka, E. Tashiro, E. Yonemochi, T. Oguchi, and K. Yamamoto, Solid-state fluorescence study of naphthalene adsorption on porous material, J. Colloid Interface Sci., 248, 239-243 (2002)
1999-2001
T. Suzuki, H. Kikuchi, S. Yamamura, K. Terada, and K. Yamamoto, The change in characteristics of microcrystalline cellulose during wet granulation using a high-shear mixer, J. Pharm. Pharmcol., 53, 609-616 (2001)
T. Suzuki, H. Kikuchi, E. Yonemochi, K. Terada, and K. Yamamoto, Interaction of Microcrystalline Cellulose and Water in Granules Prepared by a High-Shear Mixer, Chem. Pharm. Bull., 49, 373-378 (2001)
K. Nakamura, K. Katagai, K. Mori, N. Higo, S. Sato, K. Yamamoto, Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats, Int. J. Pharm., 218, 93-102 (2001)
T. Uchino, Y. Tozuka, T. Oguchi, and K. Yamamoto, The Change of the Structure of Amylose During the Inclusion of 2-Naphthol in Sealed-heating Process, J. Inclusion. Phenom. Macro. Chem., 39, 145-149 (2001)
S. Chutimaworapan, G. C Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of Nifedipine from Coevaporates Prepared with Eudragit and Poloxamer, J. Pharm. Sci. Technol. Jpn., 61, 21-33 (2001)
H.Ishii, K. Yamamoto, T. Oguchi, and Y. Tozuka, Effect of Temperature on Amorphous Form of Sparingly (Poorly) Water-Soluble Drug Prepared by Grinding, J. Jpn. Pharm. Mach. & Eng. 10, 6-12 (2001)
J. Nunthanid, S. Puttipipatkhachorn, K. Yamamoto, and G. E. Peck, Physical Properties and Molecular Behavior of Chitosan Films, Drug Dev. Ind. Pharm., 27, 143-157 (2001)
M. Ono, Y. Tozuka, T. Oguchi and K. Yamamoto, Effect of dehydration temperatures on moisture absorption and dissolution behavior of theopphylline, Chem.Pharm.Bull., 49, 1526-1530 (2001)
L. M. Zhou, J. Sirithunyalug, E. Yonemochi, T. Oguchi and K. Yamamoto, Complex Formation between Erythritol and 4-Hexylresorcinol, J. Thermal Anal. Calorimetry, 59, 951-960 (2000)
A. Koda, S. Ito, S. Itai, and K. Yamamoto, Characterization of Chloramphenicol Palmitate From C and Absorption Assessments of Chloramphenicol Palmitate Polymorphs, J. Pharm. Sci. Technol. Jpn., 60, 43-52 (2000)
S. Chutimaworapan, G. C. Ritthidej, T. Oguchi, and K. Yamamoto, Fast Release and Physicochemical Characteristics of Nifedipine Solid Dispersions with Poloxamers, J. Pharm. Sci. Technol. Jpn., 60, 77-87 (2000)
Y. Kobayashi, S. Ito, S. Itai, and K. Yamamoto, Physicochemical Properties and bioavailability of carbamazepine polymorphs and dihydrate, Int. J. Pharm., 193, 137-146 (2000)
M. Ohta, Y. Tozuka, T. Oguchi and K. Yamamoto, Evaluation of Physicochemical Stability of Amorphous Cefditren Pixoxil, Using Modulated-Temperature Differential Scanning Calorimetry, J. Pharm. Sci. Technol., Jpn., 60, 160-165 (2000)
T. Oguchi, K. Ishidoh, T. Hanawa, S. Piyarom, and K. Yamamoto, Inclution Compound Formation of α-Cyclodextrin with Polyethylene Glycol Induced by Heat Treatment, J. Pharm. Sci. Technol., Jpn., 60, 139-147 (2000)
M. Ohta, Y. Tozuka, T. Oguchi, and K. Yamamoto, Water Vapor Adsorption Properties of Amorphous Cefditren Pivoxil Evaluated by Adsorption Isotherms and Microcalorimetry, Drug Dev. Ind. Pharm., 26, 643-649 (2000)
Y. Tozuka, E. Yonemochi, T. Oguchi and K. Yamamoto, Molecular States of 2-Naphthoic Acid in Solid Disersions with Porous Crystalline Cellulose, as Investigated by Fluorescence Spectroscopy, Bull. Chem. Soc., Jpn., 73, 1567-1572 (2000)
S. Chutimaworapan, G. C. Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of nifedipine from Microspheres Spray Dried with Eudragit and Polyvinylpyrrolidone, J. Pharm. Sci. Technol., Jpn., 60, 77-87 (2000)
T. Oguchi, K. Kazama, E. Yonemochi, S. Chutimaworapan, W. S. Choi, S. Limmatvapirat, and K. Yamamoto, Specific complexation of ursodeoxycholic acid with guest compounds induced by co-grinding, Phys. Chem. Chem. Phys., 2, 2815-2820 (2000)
S. Chutimaworapan, G. C Ritthidej, T. Oguchi, and K. Yamamoto, Controlled Release of Nifedipine from Microspheres Spray Dried with Eudragit and Polyvinylpyrrolidone, J. Pharm. Sci. Technol. Jpn., 60, 196-206 (2000)
S. Okonogi, T. Oguchi, E. Yonemochi, S. Puttipipatkhachorn and K. Yamamoto, Physicochemical Properties of Ursodeoxycholic Acid in Solid Dispersion with Controlled Pore Glass, J. Colloid Interface Sci., 216, 276-284 (1999)
E. Yonemochi, S. Kitahara, S. Maeda, S. Yamamura, T. Oguchi and K. Yamamoto, Physicochemical Properties of Amorphous Clarithromycin obtained by Grinding and Spray Drying, Eur. J. Pharm. Sci., 7, 331-338 (1999)
M. Ohta, Y. Tozuka, T. Oguchi and K. Yamamoto, Comparison of Crystallinity of Cefditoren Pivoxil Determined by X-Ray, Differential Scanning Calorimetry and Microcalorimetry, Chem.Pharm.Bull., 47, 1638-1640 (1999)
M. Ohta, T. Oguchi and K. Yamamoto, Evaluation of solubility parameter to predict apparent solubility of amorphous and crystalline cefditoren pivoxil, Pharmaceutica Acta Helvetiae, 74, 59-64 (1999)
1996-1998
F. Usui, K. Maeda, A. Kusai, M. Ikeda, K. Nishimura, and K. Yamamoto, Dissolution Improvement of 3RS-8359 by the Solid Dispersion Prepared by the Solvent Method., Int. J. Pharm., 170, 247-256 (1998)
E. Yonemochi, S. Kitahara, S. Maeda, S. Yamamura, T. Oguchi and K. Yamamoto: Physicochemical Properties of Amorphous Clarithromycin obtained by Grinding and Spray Drying., Eur. J. Pharm. Sci., 6, 324-329 (1998)
T. Oguchi, S. Limmatvapirat, C. Takahashi, S. Sungthongjeen, W. S. Choi, E. Yonemochi and K. Yamamoto: Effect of Guest Species on Inclusion Compound Formation of Deoxycholic Acid by Co-grinding, Bull. Chem. Soc. Jpn.,71, 1573-1579 (1998)
Y. Tozuka, E. Yonemochi, T. Oguchi and K. Yamamoto: Fluorometric Studies of Pyrene Adsorption on Porous Crystalline Cellulose, J. Colloid Interface Sci., 205, 501-505 (1998)
Y. Ueno, E. Yonemochi, T. Tozuka, S. Yamamura, T. Oguchi and K. Yamamoto: Charaterization of Ursodeoxycholic Acid Amorphous Prepared by Spray-Drying Method, J. Pharm. Pharmcol. 50, 1213-1219 (1998)
T. Oguchi, H. Yamasato, S. Limmatvapirat, E. Yonemochi and K. Yamamoto: Structural Change and Complexation of Strictly Linear Amylose Induced by Sealed-Heating with Salicylic Acid, J. Chem. Soc. Faraday Trans., 94, 923-927 (1998)
H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto: The Effect of Water Content and Crystalliniyt of the Heptakis-(2,6-di-O-methyl)-β-cyclodextrin on the Physicochemical Properties of a Sealed Heated Compound with Naphthalene, J. Soc. Powder Tech. Jpn., 35, 353-359 (1998)
S. Limmatvapirat, E. Yonemochi, T. Oguchi and K. Yamamoto: Mechanochemical Complexation between Deoxycholic Acid and Salicylic Acid, J. Incl. Phenom. Recog. Chem., 31, 367-379 (1998)
K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi and K, Yamamoto: Effect of Pore Size on the Gaseous Adsorption of Ethenzamide on Porous Crystalline Cellulose and the Physicochemical Stability of Ethenzamide after Storage, Chem. Pharm. Bull., 46, 314-318 (1998)
M. Fukahori, K. Kakinuma, M. Seki, H. Takahashi, Y. Uchino, H. Sato, and K. Yamamoto: Effects of Added Lower Alcohols on Solubilized Tocopherol Acetate Sorption to Polyethylene Film in Aqueous Solution, Chem. Pharm. Bull., 44, 196-200 (1997)
K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto, Aspirin Hydrolysis in Mixtures with Porous Crystalline Cellulose., Drug Stability, 1, 92-97 (1997)
S. Okonogi, T. Oguchi, E. Yonemochi, S. Puttipipatkhachorn, and K. Yamamoto: Improved Dissolution of Ofloxacin via Solid Dispersion, Int. J. Pharm., 156, 175-180 (1997)
T. Oguchi, Y. Tozuka, S. Okonogi, E. Yonemochi, and K. Yamamoto: Improved Dissolution of Naproxen from Sohd Dispersions with Porous Additives, J. Pharm. Sci. Technol., Jpn.,. 57, 168-173 (1997)
K. Yano, A. Kajiyama, M. Hamada, and K. Yamamoto: Constitution of Colloidal Particles Formed from a Solid Dispersion System, Chem. Pharm. Bull., 45, 1339-1344 (1997)
F. Usui, K. Maeda, A. Kusai,K. Nishimura, and K. Yamamoto : Inhibitory Effects of Water-Soluble Polymers on Pfecipitation of RS-8359, Int. J. Pharm., 154, 59-66 (1997)
S. Lim matvapifat, E. Yonemochi, T. Oguchi, and K. Yamamoto: Complex Formation between Deoxycholic Acid and Menadione by Grinding and Sealed Heating Methods, Chem. Pharm. Bull., 45, 1358-1362 (1997)
K. Yano, A. Kajiyama, N. Itoh, J. Shimaya, and K. Yamamoto: Improvement of Bioavailability of Poorly Water-soluble Drug by Nanoparticles from a Solid Dispersion System, Yakuzaigaku, 57, 95-101 (1997)
S. Limmatvapirat, K. Yamaguchi, E. Yonemochi, T. Oguchi, and K. Yamamoto: A 1 : 1 Deoxycholic Acid-Salicylic Acid Complex, Acta Cryst., C53, 803-805 (1997).
S. Piyarom, E. Yonemochi, T. Oguchi, and K. Yamamoto: Effects of Grinding and Humidification on the Transformation of Conglomerate to Racemic Compound in Optically Active Drugs, J. Pharm. Pharmacol., 49, 384-389 (1997)
E. Yonemochi, Y. Ueno, T. Ohmae, T. Oguchi, S. Nakajima, and K. Yamamoto: Evaluation of Amorphous Ursodeoxychohc Acid by Thermal Methods, Pharm. Res., 14, 798-803 (1997)
S. Ito, M. Nishimura, Y. Kobayashi, S. Itai, and K. Yamamoto: Characterization of Polymorphs and Hydrates of GK-128, a Serotonin 3 Receptor Antagonist, Int. J. Pharm., 151, 133-143 (1997)
S. Okonogi, E. Yonemochi, T. Oguchi, S. Puttipipatkhachorn, and K. Yamamoto: Enhanced Dissolution of Ursodeoxycholic Acid from the Solid Dispersion, Drug Dev. Ind. Pharm., 23, 1-7 (1997)
S. Ito, Y. Kobayashi, M. Nishimura, K. Matsumoto, S. Itai, and K. Yamamoto: Effect of Pulverization on Dehydration Behavior of Crystals of GK-128, a Serotonin 3 Receptor Antagonist, J. Pharm. Sci., 85, 1117-1122 (1997)
K. Matumoto, T. Kimura, Y. Nakai, E. Yonemochi, T. Oguchi, Y. Yamamoto: Relationship between the Physical Properties of Various Lactoses on the Market and Characteristics of Their Tablets, Yakuzaigaku, 57, 1-7 (1997)
Z. Yang, E. Yonemochi, H. Seki, K. Yano, K. Yamamoto: Molecular Interaction in Solvents between Pharmaceutical Excipients and Water Insoluble Drug (r)-1-[2,3-Dihydro-1-(2’-methylphenacyl)-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]-3-(3-methyl-phenyl)urea, Yakuzaigaku, 56, 224-231 (1996)
Y. Yano, A. Kajiyama, S. Yamazaki, Y. Matsumura, K. Watanabe, and K. Yamamoto: ln vitro Stability and in vivo Absorption Studies of Colloidal Particles Formed from a Solid Dispersion System, Chem .Pharm.Bull., 44, 2309-2313 (1996)
T. Ushio R. Tamura, H. Takahashi, N. Azuma, and K. Yamamoto: Unusual Enantiomeric Resolution Phenomenon Observed upon Recrystallization of a Racemic Compound, Angew. Chem. Int. Ed. Engl., 35, 2372-2374 (1996)
T. Ushio, K. Endo, and K. Yamamoto Physicochemical Properties of Suplatast Tosilate Racemate and Enantiomers, Yakugaku Zasshi, 116, 866-875 (1996)
T. Ushio, K. Endo, and K. Yamamoto Physicochemical Properties of Suplatast Tosilate Racemate and Enantiomers, Yakugaku Zasshi, 116, 866-875 (1996)
T. Oguchi, K. Kojima, D. Watanabe, E. Yonemochi, and K. Yamamoto: Preparation of Inclusion Complexes of 1-Adamantanol with Heptakis-(2,6-di-O-methyl)-β-cyclodextrin by Sealed-Heating, Yakuzaigaku, 56, 92-102 (1996)
K. Yamamoto, T. Nakao, E. Yonemochi, and T. Oguchi: Time Resolved Fluorescent Analysis for Sealed Heating of Dimethyl-β-cyclodextrin and Naphthalene System, J. Incl. Phenom. Recog. Chem, 25, 121-124 (1996)
D. Watanabe, M. Ohta, Z. J. Yang, E. Yonemochi, T. Oguchi, and K. Yamamoto: Formation of a Heptais-(2,6-di-O-methyl)-β-cyclodextrin - p-Nitrophenol Inclusion Compound by Sealed-Heating, Chem. Pharm. Bull., 44, 833-836 (1996)
M. Fukahori, K. Kakinuma, M. Seki, H. Takahashi, Y. Uchino, H. Sato, and K. Yamamoto: Effects of Added Lower Alcohols on Solubilized Tocopherol Acetate Sorphon to Polyethylene Film in Aqueous Solution, Chem.Pharm.Bull., 44, 196-200 (1996)
K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto: Aspirin Hydrolysis in Mixtures with Porous Crystalline Cellulose, Drug Stability, 1, 92-97 (1996)
1994-1995
A. Watanabe, T. Hanawa, M. Sugihara, and K. Yamamoto: Development and Pharmaceutical Properties of a New Oral Dosage Form of Theophylline using Sodium Caseinate for the Possible Use in Elderly Patients, Int. J. Pharm., 117, 23-30 (1995)
T. Hanawa, R. Ikoma, A. Watanabe, M. Sugihara, T. Oguchi, and K. Yamamoto: Dissolution Behavior of Acetaminophen from Powder and Tablets of Ground Mixture of Acetaminophen with Florite RE and Polyethylene Glycol 6000, Jpn. J. Hosp.Pharm., 21, l-8 (1995)
H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto: Factors Affecting the Formation in the Solid State of the Metastable Complex between Naphthalene and Dimethyl-β-Cyclodextrin, J. Inclusion Phenom. Mol. Recognit. Chem., 23, 65-72 (1995)
S. Maeda, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto: Determination of Partial Solubility Parameters of Lactose and Its Application to Solubility Evaluation, Yakugaku Zasshi, 115, 234-240 (1995)
E. Yonemochi, M. Kojima, A. Nakatsuji, S. Okonogi, T. Oguchi, Y. Nakai, and K. Yamamoto: Thermal Behavior of Methyl p-Hydroxybenzoate in Controlled-Pore Glass Solid Dispersion, J. Colloid lnterface Sci., 173, 186-191 (1995)
K. Moribe, E. Yonemochi, T. Oguchi, Y. Nakai, and K. Yamamoto: Peculiar Peak Shifts in the IR Spectrum of Benzoic Acid Crystals by Compression with Methylated Additives, Chem. Pharm. Bull., 43, 666-670 (1995)
T. Oguchi, E. Yonemochi, and K. Yamamoto: Freeze-Drying of Drug-Additive Binary Systems. Effects of Saccharide Addition on the Crystallization Sodium in Frozen Aqueous Solution, Pharm. Acta Helv., 70, 113-116 (1995)
T. Hanawa, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto: Characterization of Thermal Behavior of Physical Mixtures of Heptakis (2,6-di-O-methyl)-β-cyclodextrin with Benzoic Acid of p-Hydroxybenzoic Acid Esters, Netsu Sokutei, 22, 11-15 (1995)
T. Oguchi, K. Matsumoto, E. Yonemochi, Y. Nakai, and K. Yamamoto: Dissolution Studies in Organic Solvents for Evaluating Hydrogen-Bond Matrix of Cellulose in the Ground Mixture, Int. J. Pharm., 113, 97-102 (1995)
T. Ushio and K. Yamamoto: High-Performance Liquid Chromatography of Enantiomers of {2-[4-(3-Ethoxy-2-hydroxypropoxy)phenylcarbamoyl]ethyl}-dimethylsulfoniumu-p-toluenesulfonate (Suplatast tosilate) on a Cellulose Tris-3,5-dimethylphenyl-carbamate Column, J. Chromatogr. A, 684, 235-242 (1994)
A. Watanabe, T. Hanawa, M. Sugihara, and K. Yamamoto: Release Profiles of Phenytoin from New Oral Dosage Form for the Elderly, Chem. Pharm. Bull., 42, 1642-1645 (1994)
H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto: Complex Formation between Naphthalene and Di-methyl-β-cyclodextrin by Heating in a Sealed Ampoule, J. Chem. Soc. Faraday Trans., 90, 3117-3119 (1994)
H. Kawashima, E. Yonemochi, T. Oguchi, and K. Yamamoto : Meta-Stable Complex Formation between 2,6-Di-O-methyl-β-cyclodextrin and Naphthalene During Sealed-Heating Process, Chem. Pharm. Bull., 42, 727-72 (1994)
T. Hanawa, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto: Effects of Vapor Pressure of Guest Compounds on the Bound Molar Ratio to Heptakis-(2,6-di-O-methyl)-β-cyclodextrin, Yakuzaigaku, 54, 221-226 (1994)
E. Yonemochi, K. Oda, S. Saeki, T. Oguchi, Y. Nakai, and K. Yamamoto: Physicochemical Properties of Amorphous Ursdeoxycholic Acid Obtained by Grinding, Chem. Pharm. Bull., 42, 1948-1950 (1994)
K. Matsumoto, Y. Nakai, E. Yonemochi, T. Oguchi, and K. Yamamoto: Physicochemical Characterstics of Porous Crystalline Cellulose and Formation of an Amorphous State of Ethenzamide by Mixing, Int. J. Pharm., 108, 167-172 (1994)
K. Yamamoto, T. Oguchi, E. Yonemochi, T. Matsumura, and Y. Nakai: Fluorometric Study of 2,5-Dipheny1oxazole in Ground Mixtures with γ-Cyclodextrin, Pharm. Res., 11, 331-336 (1994)
1992-1993
T. Uchida, E. Yonemochi, T. Oguchi, K. Terada, K. Yamamoto, and Y. Nakai: Polymorphism of Tegafur: Physico-chemical Properties of Four Polymorphs, Chem. Pharm. Bull., 41, 1632-1635 (1993)
T. Yamaguchi, M Nishimura, R. Okamoto, T. Takeuchi, K. Yamamoto: Dissolution and Recrystallization Characteristics of Amorphous 3-O-Acetyl-4-O-isovaleryltylosin, Yakuzaigaku, 53, 249-256 (1993)
T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, K. Yamamoto: Polymorphic Characterization of 3-O-Acetyl-4-O-isovalerytylosin, Yakuzaigaku, 53, 235-241 (1993)
T. Yamaguchi, M. Nishimura, H. Iguchi, R. Okamoto, T. Takeuchi, K. Yamamoto: Improvement of Pharmaceutical Properties of 4-O-(4-methoxyphenyl) acetyltylosin Using Solid Dispersion with Carboxymethylcellulose, Yakuzaigaku, 53, 221-228 (1993)
K. Yamamoto, K. Saito, H. Kawashima, E. Yonemochi, T. Oguchi, and Y. Nakai: Molecular States of Pyrene in the Ground Mixtures with Cyclodextrins Studied by Fluorescence Spectroscopy, Nippon Kagaku Kaishi, 1141-1147 (1993)
T. Hanawa, E. Yonemochi, T. Oguchi, and K. Yamamoto: Thermal Behavior of Ground Mixtures of Heptakis(2,6-di-O-methyl)-β-cyclodextrin and Benzoic Acid., J. Inclusion Phenom. Mol. Recognit. Chem., 15, 91-101 (1993)
E. Yonemochi, T. Oguchi, K. Yamamoto, and Y. Nakai: Acceleration of the Addition Reaction of Succinic Anhydride and p-Nitroaniline in Synthetic Aluminum Silicate, Advanced Powder Tochnol., 4, 41-48 (1993)
T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, and K. Yamamoto: Physico-chemical Stability of Glassy 16-Membered Macrolide Compounds, Chem. Pharm. Bull., 41, 1812-1816 (1993)
T. Uchida, E. Yonemochi, T. Oguchi, K. Terada, K. Yamamoto, and Y. Nakai: Polymorphism of Tegafur: Physico-chemical Properties of Four Polymorphs, Chem. Pharm. Bull., 41, 1632-1635 (1993)
T. Yamaguchi, M. Nishimura, R. Okamoto, T. Takeuchi, and K. Yamamoto : Glass Formation of 4-O-(4-Methoxyphenyl)acetyltylosin and Physicochemical Stability of the Amorphous Solid, Int. J. Pharm., 85, 87-96 (1992)
A. S. Ali, K. Yamamoto, A. M. El-Sayed, F. S. Habib, and Y. Nakai: Molecular Behavior of Flufenamic Acid in Physical and Ground Mixtures with Florite, Chem. Pharm. Bull., 40, 1289-1294, (1992)
T. Oguchi, J. Yamashita, E. Yonemochi, K. Yamamoto, and Y. Nakai: Effects of Saccharide on the Decomposition of Cephalothin Sodium and Benzylpenicilline Potassium in Freeze-Dried Preparations, Chem. Pharm. Bull., 40, 1061-1063 (1992)
H. Egawa, S. Maeda, E. Yonemochi, T. Oguchi, K. Yamamoto, and Y. Nakai: Solubility Parameter and Dissolution Behavior of Cefalexin Powders with Different Crystallinity, Chem. Pharm. Bull., 40, 819-820 (1992)
A. S. Ali, K. Yamamoto, A. M. El-Sayed, F. S. Habib, and Y. Nakai: Molecular Interaction between Benzoic Acid and Florite and Complex Formation, Chem. Pharm. Bull., 40, 467-471 (1992)
