Publications (Arai)

Arai, S.; Inagaki, S.; Nakajima, M.; Nishida, A.

“Regio-divergent Nickel Catalysis: Intramolecular [4+2] and [2+2] Cycloaddition Reactions Between Vinylallenes and Alkynes”

Chem. Commun. 2021, 57, 11268-11271.


Kawata, Y.; Arai, S.; Nakajima, M.; Nishida, A.

“Regio- and stereoselective synthesis of cyclobutanes by nickel-catalyzed homodimerizative [2 + 2] cycloaddition using allenamides.”

Tetrahedron Lett. 2021, 69, 152974.


Shigeru Arai, Atsushi Nishida

“Synthesis of Nitrogen Heterocycles through Cyanative Cyclization and Cycloaddition Reactions under Transition Metal Catalysis”
Heterocycles 2020, 100, 1949-1978.


Arai, S.; Sato, Y.; Ito, N.; Nishida, A.

“Cobalt-catalyzed hydrocyanation and hydroarylation of enamines.”

Tetrahedron Lett. 2019, 60, 151314-151317.


Arai, S.; Kawata, Y.; Amako, Y.; Nishida, A.

“Nickel-catalyzed [2+2] cycloaddition reaction using bisallenes.”

Tetrahedron Lett. 2019, 60, 151168-151171.


Arai, S.; Izaki, A.; Amako, Y.; Nakajima, M.; Uchiyama, M.; Nishida, A.

“Regioselective [2+2+2] cycloaddition reaction using allene-ynes with simple allenes under nickel catalysis.”

Adv. Syn. Catal. 2019, 361, 4882-4887.

Selected as Very Important Publication (VIP) and front cover picture.


Hori, H.; Arai, S.; Nishida, A.

“Cobalt-catalyzed cyclization with the introduction of cyano, acyl and aminoalkyl groups.”

Org. Biomol. Chem. 2019, 17, 4783-4788.


荒井秀、天児由佳、堀弘人、西田篤司

“ニッケル触媒を用いる炭素炭素多重結合へのヒドロシアノ化反応とその応用”

有機合成化学協会誌、2019, 77, 341-349.


Arai, S.

“Nickel-catalyzed Hydrocyanation of Allenes and Its Application”

Chem. Pharm. Bull. 2019, 67, 397-403.


Arai, S.; Nakazawa, K.; Yang, X.-F.; Nishida, A.

“Nickel-catalyzed regioselective hydrocyanation of terminal alkynes by assistance of a tosyl group.”

Tetrahedron 2019, 75, 2482-2485.


Shigeru Arai, Koki Matsumoto, Atsushi Nishida.

“Cu-catalyzed regio- and stereoselective sulfonylation of multi-substituted allenes.”

Tetrahedron 2019, 75, 1145-1148.


Shigeru Arai, Masaya Nakajima,AtsushiNishida.

“Total Synthesis of Lundrines and Related Alkaloids”

J. Synth. Org. Chem., Jpn. 2018, 76, 668-677.


Kouki Matsumoto, Shigeru Arai, Atsushi Nishida

“Formal Synthesis of (±)-Quebrachamine through regio- and stereoselective hydrocyanation of arylallene”

Tetrahedron 2018, 74, 2865-2870.

“Olefin-migrative Cleavage of Cyclopropane Rings through the Nickel-catalyzed Hydrocyanationof Allenes and Alkenes.”

Hori, H. Arai, S., Nishida A.

Adv. Syn. Catal. 2017, 359, 1170.


“Transfer of Axial Chirality Through the Nickel-catalyzed Hydrocyanation of Chiral Allenes.”

Amako Y. Arai, S., Nishida A.

Org. Biomol. Chem. 2017, 15, 1612-1617.


“Furan-Iminium Cation Cyclization (FIC) in A Total Synthesisof Manzamine Alkaloids”

Tokumaru,K.; Ohfusa,T.; Arai,S.; Nishida, A.

J. Antibiotics 2016, 69, 340-343.


“Total Syntheses of (+)-Grandilodine C and (+)-Lapidilectine B and Determination of their Absolute Stereochemistry”

Masaya Nakajima, Shigeru Arai and Atsushi Nishida

Angew. Chem. Int. Ed. 2016, 55, 3473-3476.

<highlighted by SYNFACTS 2016, 12, 437.>


“A New Protocol for Nickel-catalysed Regio- and Stereoselective Hydrocyanation of Allenes.”

Shigeru Arai, Hiroto Hori, Yuka Amako, and Atsushi Nishida.

Chem. Commun. 2015, 51, 7493-7496.


“Asymmetric Total Synthesis of (-)-Lundurine B and Determination of Its Absolute Stereochemistry.”

Masaya Nakajima, Shigeru Arai, and Atsushi Nishida.

Chem. Asian J. 2015, 10, 1065-1070.


“A Concise and Versatile Synthesis of Alkaloids from Kopsia tenuis: Total Synthesis of (±)-Lundurine A and B.”

Shigeru Arai, Masaya Nakajima, and Atsushi Nishida.

Angew. Chem. Int. Ed. 2014, 53, 5569-5571.

<highlighted by SYNFACTS 2014, 10, 789.>


“Total Synthesis of (±)-Lundurine B.”

Masaki Hoshi, Osamu Kaneko, Masaya Nakajima, Shigeru Arai, and Atsushi Nishida.

Org. Lett. 2014, 16, 768-771.

<highlighted by SYNFACTS 2014, 10, 338.>


“A 2-Benzothiazolylphenyl Group Accelerates the Intramolecular [2+2] Cycloaddition of Allene-Ynes.”

Hiroto Hori, Shigeru Arai and Atsushi Nishida.

Asian J. Org. Chem. 2014, 3, 41-43.


“Total Synthesis of Schizocommunin and Revision of Its Structure.”

Uehata, Koji; Kimura, Naoki; Hasegawa, Kazuya; Arai, Shigeru; Nishida, Mayumi; Hosoe, Tomoo; Kawai, Ken-ichi; Nishida, Atsushi.

Journal of Natural Products 2013, 76(11), 2034-2039.


“Catalytic Cyanation of Carbon-Carbon Triple Bonds Through a Three-Component Cross-Coupling Reaction under Nickel Catalysis.”

Yang, Xiaofei; Arai, Shigeru; Nishida, Atsushi.

Advanced Synthesis & Catalysis 2013, 355(14-15), 2974-2981.


“Regioselective Hydronickelation of Allenes and Its Application to the Hydrocyanative Carbocyclization Reaction of Allene-Ynes and Bis-Allenes.”

Amako, Yuka; Hori, Hiroto; Arai, Shigeru; Nishida, Atsushi.

Journal of Organic Chemistry 2013, 78(21), 10763-10775


“Hydrocyanative Cyclization and Three-Component Cross-Coupling Reaction between Allenes and Alkynes under Nickel Catalysis.”

Shigeru Arai, Yuka Amako, Xiaofei Yang and Atsushi Nishida.

Angew. Chem. Int. Ed. 2013, 52(31), 8147-8150.


“AntiCarbocyanative Cyclization of Enynes under Nickel Catalysis.”

Tomohiro Igarashi, Shigeru Arai, and Atsushi Nishida.

J. Org. Chem. 2013, 78(9), 4366-4372.


“Palladium-Catalyzed Cyanation of Non-Activated Alkynes; Development of Cyanopalladationand Its Application to Cyclization and Cycloaddition Reactions.”

Arai, S.; Nishida, A.

Synlett 2012, 23, 2880-2893. (invited accounts).


“Catalytic dicyanative 5-exo- and 6-endo-cyclization triggered by cyanopalladation of alkynes.”

Shigeru Arai, Yuka Koike, and Atsushi Nishida.

Adv. Synth. Catal. 2010, 352, 893-900.


“Catalytic Dicyanative [4 + 2] Cycloaddition Triggered by Cyanopalladation Using Ene-Enynes and Cyclic Enynes with Methyl Acrylate.”

Shigeru Arai, Yuka Koike, Hirohiko Hada, and Atsushi Nishida.

J. Org. Chem. 2010, 75, 7573-7579.


“Catalytic Dicyanative [4+2] Cycloaddition Triggered by Cyanopalladation of Conjugated Enynes under Aerobic Conditions.”

Shigeru Arai, Yuka Koike, Hirohiko Hada, and Atsushi Nishida.

J. Am. Chem. Soc. 2010, 132, 4522-4523.


“Palladium-Catalyzed Cyanation of Carbon-Carbon Triple Bonds under Aerobic Conditions.”

Arai, S.; Sato, T.; Koike, Y.; Hayashi, M.; Nishida, A.

Angew. Chem. Int. Ed. 2009, 48, 4528-4531.

<highlighted in Synth. Org. Chem. Jpn. 2010, 68, 567.>


“Asymmetric synthesis of hydroisoquinoline derivatives, a key intermediate for manzamine synthesis, by Diels-Alder reaction using 4-amino-2-siloxybutadiene.”

Mihara, Yasuhiro; Matsumura, Tomoaki; Terauchi, Yuki; Akiba, Masakatsu; Arai, Shigeru; Nishida, Atsushi.

Bulletin of the Chemical Society of Japan 2009, 82(12), 1520-1527.


“Catalytic 1,2-Dicyanation of Alkynes by Palladium(II) under Aerobic Conditions.”

Arai, Shigeru; Sato, Takashi; Nishida, Atsushi.

Advanced Synthesis & Catalysis 2009, 351(11+12), 1897-1904.


“Novel Synthesis of Cinnolines and 1-Aminoindolines via Cu-Catalyzed Intramolecular N-Arylation of Hydrazines and Hydrazones Prepared from 3-Haloaryl-3-hydroxy-2-diazopropanoates.”

Kazuya Hasegawa, Naoki Kimura, Shigeru Arai, and Atsushi Nishida.

J. Org. Chem., 2008, 73(16), 6363-6368.


“Synthetic Study of Manzamine B; Synthesis of the Tricyclic Central Core by an Asymmetric Diels-Alder and RCM Strategy.”

Tomoaki Matsumura, Masakatsu Akiba, Shigeru Arai, Masako Nakagawa and Atsushi Nishida.

Tetrahedron Letters. 2007, 48, 1265-1268.


“Catalytic Asymmetric Michael Reaction under Phase-Transfer Catalysis; Construction of Chiral Tetrasubstituted Carbon and its Application to the Synthesis of a Chiral Pyrrolidone.”

Shigeru Arai, Fumie Takahashi, Riichiro Tsuji, and Atsushi Nishida.

Heterocycles, 2006, 67, 495-501.


“Synthesis of alpha-Diazo-beta-hydroxyesters through a One-Pot Protocol by Phase-Transfer Catalysis: Application to Enantioselective Aldol-Type Reaction and Deastereoselective Synthesis of alpha-Amino-beta-hydroxyester Derivatives.”

Kazuya Hasegawa, Shigeru Arai, and Atsushi Nishida.

Tetrahedron, 2006, 62, 1390-1401."


“Stereoselective Furan-Iminium Cation Cyclization in the Construction of the Core Structure of Manzamine A.”

Kazuyuki Tokumaru, Shigeru Arai and Atsushi Nishida.

Organic Letters, 2006, 8, 27-30.


“Synthesis of a-Diazo-b-hydroxyesters through a One-Pot Protocol by Phase-Transfer Catalysis: Application to Enantioselective Aldol-Type Reaction and Deastereoselective Synthesis of a-Amino-b-hydroxyester Derivatives.”

Kazuya Hasegawa, Shigeru Arai, and Atsushi Nishida.

Tetrahedron, 2006, 62, 1390-1401.


“Catalytic Asymmetric Michael Reaction under Phase-Transfer Catalysis; Construction of Chiral Tetrasubstituted Carbon and its Application to the Synthesis of a Chiral Pyrrolidone.”

Shigeru Arai, Fumie Takahashi, Riichiro Tsuji, and Atsushi Nishida.

Heterocycles, 2006, 67, 495-501.


“Facile and Regioselective Dealkylation of Arylalkylethers Using Niobium(V) Pentachloride.”

Yukinori Sudo, Shigeru Arai, and Atsushi Nishida.

Euro. J. Org. Chem. 2006, 3, 752-758.


“Facile Synthesis of Vicinal Diamines Promoted by Low-valent Niobium: The Preparation of Chiral Octahydrobisisoquinolines and its Application to Catalytic Asymmetric Synthesis.” 

Shigeru Arai, Satoshi Takita, and Atsushi Nishida.

Euro. J. Org. Chem. 2005, 5262-5267.


“Diastereoselective Fischer-Type Pyrroloindole Synthesis and Its Application to the Synthesis of Chiral Pyrroloindole Alkaloids.” Atsushi Nishida, Satoru Ushigome, Ayako Sugimoto, and Shigeru Arai.

Heterocycles, 2005, 66, 181-185.


“Niobium Pentachloride-Silver Perchlorate as an Efficient Catalyst in the Friedel-Crafts Acylation and Sakurai-Hosomi Reaction of Acetals.”

Shigeru Arai, Yukinori Sudo, and Atsushi Nishida.

Tetrahedron, 2005, 61, 4639-4642.


“One-pot Synthesis of α-Diazo-β-hydroxyesters under Phase-Transfer Catalysis and Application to the Catalytic Asymmetric Aldol Reaction.”

Shigeru Arai, Kazuya Hasegawa and Atsushi Nishida.

Tetrahedron Letters, 2004, 45, 1023-1026.


“A Highly Diastereoselective Pinacol Coupling Reaction of Aldehydes and Ketones Using Low-valence Niobium Generated from Nb(V).”

Shigeru Arai, Yukinori Sudo and Atsushi Nishida.

Chem. Pharm. Bull., 2004, 52 (2), 287-288.


“Novel Synthesis of Fused Indoles by the Palladium-Catalyzed Cyclization of N-Cycloalkenyl-o-haloanilines.”

Takeshi Watanabe, Shigeru Arai, Atsushi Nishida.

Synlett, 2004, 907-909.


“A Simple and Regioselective Carbon-Oxygen Bond Cleavage Using Niobim(V).”

Shigeru Arai, Yukinori Sudo and Atsushi Nishida.

Synlett, 2004, 1104-1106.


“General Method for the Synthesis of Chiral 2,3-Bisarylmethoxy-1,4-butanediols from (L)-(+)-Tartarate.”

Riichiro Tsuji, Shigeru Arai, Atsushi Nishida.

Synthesis, 2004, 960-966 (Featured Article).

YAMATSUGU GROUP’s  publications