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Hiroko Nakatsukasa

Laboratory of Microbiology and Immunology
Graduate School of Pharmaceutical Sciences, Chiba University 　　　

EDUCATION
2011 PhD in Pharmaceutical Science
         Graduate School of Pharmaceutical Sciences, Tokyo University of Science
2008 MS in Pharmaceutical Science
         Graduate School of Pharmaceutical Sciences, Tokyo University of Science
2006 BS in Pharmaceutical Science
         Faculty of Pharmaceutical Sciences, Tokyo University of Science
 
EMPLOYMENT
2022.4 - present  Associate Professor
 Laboratory of Microbiology and Immunology, Graduate School of Pharmaceutical Sciences, Chiba University
2017.7 - 2022.3   Assistant Professor
 Department of Microbiology and Immunology, Keio University School of Medicine
2014.4 - 2017.6  Project Assistant Professor
 Department of Microbiology and Immunology, Keio University School of Medicine
2011.4 - 2014.5  Visiting Fellow
 National Institute of Dental and Craniofacial Research, National Institutes of Health (USA)

Pharmacist (2006)

Komai K, Ito M, Nomura S, Shichino S, Katoh M, Yamada S, Ko T, Iizuka-Koga M, Nakatsukasa H, Yoshimura A. Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure. Front Immunol. Oct 20;12:763647 (2021)
 
MaruYama T, Kobayashi S, Nakatsukasa H, Moritoki Y, Taguchi D, Sunagawa Y, Morimoto T, Asao A, Jin W, Owada Y, Ishii N, Iwabuchi Y, Yoshimura A, Chen W, Shibata H. The curcumin analog GO-Y030 controls the generation and stability of regulatory T cells. Front. Immunol. Jun 23;12:687669 (2021)
 
Kasagi S, Wang D, Zhang P, Zanvit P, Chen H, Zhang D, Li J, Che L, Maruyama T, Nakatsukasa H, Wu R, Jin W, Sun L, Chen W. Combination of apoptotic T cell induction and self-peptide administration for therapy of experimental autoimmune encephalomyelitis. EBioMedicine. 44:50-59 (2019)
 
Nakatsukasa H, Oda M, Yin J, ChikumaS, Ito M, Koga-Iizuka M, Someya K, Kitagawa Y, Ohkura N, Sakaguchi S, Koya I, Sanosaka T, Kohyama J, Tsukada Y, Yamanaka S, Takamura-Enya T, Lu Q, and Yoshimura A. Loss of TET proteins in regulatory T cells promotes abnormal proliferation, Foxp3 destabilization, and IL-17 expression. Int Immunol. 31(5):335-347 (2019)
 
Ito M, Komai K, Mise-Omata S, Iizuka-Koga M, Noguchi Y, Kondo T, Sakai R, Matsuo K, Nakayama T, Yoshie O, Nakatsukasa H, Chikuma S, Shichita T, Yoshimura A. Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery. Nature. 565(7738):246-250 (2019)
 
Kanamori M, Nakatsukasa H, Ito M, Chikuma S, Yoshimura A. Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status. Int Immunol. 30(8):357-373 (2018)
 
Hibino S, Chikuma S, Kondo T, Ito M, Nakatsukasa H, Omata-Mise S, Yoshimura A. Inhibition of Nr4a receptors enhances anti-tumor immunity by breaking Treg-mediated immune tolerance. Cancer Res. 78(11):3027-3040 (2018)
 
Kasahara H, Kondo T, Nakatsukasa H, Chikuma S, Ito M, Ando M, Kurebayashi Y, Sekiya T, Yamada T, Okamoto S, Yoshimura A. Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model. Int Immunol. 29(10):457-469 (2017)
 
Someya K, Nakatsukasa H, Ito M, Kondo T, Tateda K, Akanuma T, Koya I, Sanosaka T, Kohyama J, Tsukada Y, Takamura-Enya T and Yoshimura A. Improvement of Foxp3 stability through CNS2 demethylation by TET enzyme induction and activation. Int Immunol. 1;29(8):365-375 (2017)
 
Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen Z, and Chen W. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 23(9):1036-1045 (2017)
 
Kondo T, Morita R, Okuzono Y, Nakatsukasa H, Sekiya T, Chikuma S, Shichita T, Kanamori M, Kubo M, Koga K, Miyazaki T, Kassai Y, and Yoshimura A. Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy. Nat Commun. May 22;8:15338 (2017)
 
Okada M, Kanamori M, Someya K, Nakatsukasa H, and Yoshimura A. Stabilization of Foxp3 expression by CRISPR-dCas9-based epigenome editing in mouse primary T cells. Epigenetics Chromatin. May 8;10:24 (2017)
 
Zanvit P, Konkel JE, Jiao X, Kasagi S, Zhang D, Wu R, Chia C, Ajami NJ, Smith DP, Petrosino JF, Abbatiello B, Nakatsukasa H, Chen Q, Belkaid Y, Chen ZJ, and Chen W. Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis. Nat Commun. Sep 29;6:8424. (2015)
 
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, Deng L, Zanvit P, Tu E, Jin W, Abbatiello B, Goldberg N, Chen Q, Sun L, Zhao K, Chen W. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 16(10):1077-84 (2015)
 
Kasagi S, Zhang P, Che L, Abbatiello B, Maruyama T, Nakatsukasa H, Konkel JE, Zanvit P, Jin W and Chen W. Therapy of autoimmunity by generating antigen-specific regulatory T cells in vivo through reprogramming immune system. Sci Transl Med. 6(241) 241ra78 (2014)
 
Liu X, Chen X, Zhong B, Wang A, Wang X, Chu F, Nurieva RI, Yan X, Chen P, van der Flier LG, Nakatsukasa H, Neelapu SS, Chen W, Clevers H, Tian Q, Qi H, Wei L and Dong C. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. Nature 507(7493) 513-518 (2014)
 
Zhang P, Nakatsukasa H, Tu E, Kasagi S, Cui K, Ishikawa M, Konkel JE, Maruyama T, Wei G, Abbatiello B, Wang ZQ, Zhao K, and Chen W. PARP-1 regulates expression of TGF-b receptors in T cells. Blood 122, 2224-32 (2013)
 
Nakatsukasa H, Tsukimoto M, Harada H, and Kojima S. Adenosine A2B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells. Biochem Biophys Res Commun 409, 114-119 (2011)
 
Nakatsukasa H, Tsukimoto M, Tokunaga A, and Kojima S. Repeated gamma-ray irradiation attenuates collagen-induced arthritis via up-regulation of regulatory T cells, but not by damaging lymphocytes directly. Radiat Res 174, 313-324 (2010)
 
Nakatsukasa H, Tsukimoto M, Ohshima Y, Tago F, Masada A, and Kojima S. Suppressing Effect of Low-Dose Gamma-Ray Irradiation on Collagen-Induced Arthritis. J Radiat Res 49, 381-389 (2008)