ABOUT US
Welcome to Kawashima lab!
This laboratory focuses on the functional roles of glycans in lymphocyte homing and immune responses. Lymphocyte homing is mediated by a specific interaction between the lymphocyte homing receptor L-selectin and its sulfated glycoprotein ligands expressed on high endothelial venules in the lymph nodes. We previously found that the sulfation of L-selectin ligands plays a major role in lymphocyte homing using gene-targeted mice deficient in two sulfotransferases, GlcNAc6ST-1 and GlcNAc6ST-2. We are currently investigating the roles of glycans in allergy and immune-related diseases using gene-targeted mice.
We are focusing on immunology, microbiology, and glycobiology.
Immunology
We are studying the molecular mechanism of lymphocyte dynamics that is the basis of immunity.
Microbiology
We are working on elucidating the molecular mechanism of bacterial infection and infected host responses.
Glycobiology
We are trying to elucidate the unknown function of glycans using glycosyltransferase-deficient mice and anti-glycan monoclonal antibodies.
連絡先
〒260-0856
千葉県千葉市中央区亥鼻1-8-1
医薬系総合研究棟Ⅱ 5階
千葉大学大学院薬学研究院 免疫微生物学研究室
川島 博人
電話：043-226-2926
FAX：043-226-2927
E-mail: h-kawashima@chiba-u.jp